|
|||||
|
|
| 姜黄煎对大鼠血管损伤后Bcl-2与Bax和p53的表达影响意义 | |
| 引用本文： | 董川,昌艳艳,马丽佳,郭立冬. 姜黄煎对大鼠血管损伤后Bcl-2与Bax和p53的表达影响意义[J]. 辽宁中医杂志, 2010, 0(2): 356-358 |
| 作者姓名： | 董川 昌艳艳 马丽佳 郭立冬 |
| 作者单位： | 辽宁中医药大学研究生学院;辽宁中医药大学附属一院;凌源市中医院; |
| 基金项目： | 辽宁省自然基金课题项目(600400) |
| 摘 要： | 目的:探讨姜黄煎对大鼠血管损伤后血清中Bcl-2与Bax和p53的表达影响意义。方法:模拟PCI术,采用ELISA法检测144只大鼠血清中Bcl-2与Bax和p53含量。其中姜黄煎干预组36只,生理盐水干预组36只,并与36只假手术组和36只正常组作为对照。结果:姜黄煎组,生理盐水组,假手术组,血清Bcl-2与Bax和p53含量与正常对照组比较差异明显(P0.05);假手术组血清Bcl-2水平含量接近于正常对照组,差异不明显(P0.05);姜黄煎组血清Bcl-2与Bax含量和p53含量与生理盐水干预组,假手术组比较有明显差异(P0.05);与正常对照组比较差异不明显(P0.05)。结论:姜黄煎可上调大鼠Bcl-2蛋白表达,使Bax的蛋白表达明显下降,说明Bc1-2过量表达,Bax/Bc1-2的比值增大,能抑制内皮细胞过度凋亡。二者的比例是决定细胞是否发生凋亡的重要调控因素。同时姜黄煎能够阻滞细胞周期降低P53蛋白的表达,迅速恢复内皮功能,保持完整血管内皮结构。因此,Bcl-2与Bax和p53参与了再狭窄的病理生理变化。检测患者血清Bcl-2与Bax和p53含量的异常变化,可能有助于评估血管损伤后凋亡因子对血管内皮功能和结构的影响。 |
| 关 键 词： | 姜黄煎 Bcl-2蛋白 Bax蛋白 p53基因 |
Significance of Fried Turmeric Affect to Expression of Bcl-2 and Bax and p53 of the Rats After Vascular Injury |
|
| DONG Chuan,CHANG Yan-yan,MA Li-jia,GUO Li-dong. Significance of Fried Turmeric Affect to Expression of Bcl-2 and Bax and p53 of the Rats After Vascular Injury[J]. Liaoning Journal of Traditional Chinese Medicine, 2010, 0(2): 356-358 | |
| Authors: | DONG Chuan CHANG Yan-yan MA Li-jia GUO Li-dong |
| Affiliation: | 1.Graduate School/a>;Liaoning University of Traditional Chinese Medicine/a>;Shenyang 110847/a>;Liaoning/a>;China/a>;2.the First Hospital Attached to Liaoning University of Traditional Chinese Medicine/a>;Shenyang 110032/a>;3.the First Hospital Attached to Lingyuan City Chinese Medicine Hospital/a>;Lingyuan 122500/a>;China |
| Abstract: | Objective:To investigate the significance of fried turmeric affect to expression of Bcl-2 and Bax and p53 of the rats after vascular injury.Methods:Simulate PCI operation,to detect Bcl-2 and Bax and p53 levels using ELISA in serum of 144 rats in which 36 were intervened by fried turmeric and 36 were intervened by saline,36 were sham operation and 36 normals as control group.Results:The level of Serum Bcl-2 and Bax and p53,The normal control group is different,compared with group intervened by fried turmeric... |
| Keywords: | fried turmeric Bcl-2 protein bax protein p53 gene |
| 本文献已被 CNKI 维普 等数据库收录！ | |