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| let-7与高迁移率族蛋白A在肿瘤中的研究进展 | |
| 引用本文： | 白洁,陶凯雄. let-7与高迁移率族蛋白A在肿瘤中的研究进展[J]. 国际肿瘤学杂志, 2011, 38(9): 646-649. DOI: 10.3760/cma.j.issn.1673-422X.2011.09.002 |
| 作者姓名： | 白洁 陶凯雄 |
| 作者单位： | 华中科技大学同济医学院附属协和医院腔镜外科,武汉,430022 |
| 摘 要： | 高迁移率族蛋白A(HMGA)在多种肿瘤的发生发展中起着重要的作用,其表达水平会随肿瘤恶性程度的增高或转移潜能的增大而异常增高.let-7是一类内源性非编码的微小RNA,可作为肿瘤抑制因子对HMGA基因进行负性调控.在对多种肿瘤的研究中已经观察到let-7表达水平的下降,并伴随HMGA表达水平的上升,这对肿瘤的早期诊断提... |
| 关 键 词： | 肿瘤 高迁移率族蛋白质类 let-7 |
Let-7 and HMGA in tumors |
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| BAI Jie,TAO Kai-xiong. Let-7 and HMGA in tumors[J]. Journal of International Oncology, 2011, 38(9): 646-649. DOI: 10.3760/cma.j.issn.1673-422X.2011.09.002 | |
| Authors: | BAI Jie TAO Kai-xiong |
| Abstract: | High mobility group protein A (HMGA) plays a critical role in the development of a variety of tumors.It's expression level will abnormally increase with the increase of the malignant degrees of astrocytoma and metastasis potential.Let-7 which is a kind of small RNA endogenous coding negatively regulates HMGA genes as a tumor suppressor.The expression of let-7 reduces while HMGA rises in many kinds of tumors was obversed.Therefore,this finding provides new references for the early diagnosis of tumor and also provides new approaches for therapy of tumor. |
| Keywords: | Neoplasms High mobility group proteins Let-7 |
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