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| 微小RNA与人类肿瘤 | |
| 引用本文： | 任昌振,陈欢,焦炳华. 微小RNA与人类肿瘤[J]. 国际肿瘤学杂志, 2011, 38(9): 649-652. DOI: 10.3760/cma.j.issn.1673-422X.2011.09.003 |
| 作者姓名： | 任昌振 陈欢 焦炳华 |
| 作者单位： | 200433,上海市解放军第二军医大学临床10队 |
| 摘 要： | 微小RNA(microRNA,miRNA)是一类对基因具有调控功能的内源性非编码小分子RNA.目前认为miRNA在多种生物学过程中起着至关重要的作用,包括细胞增殖、分化、凋亡等.近年研究表明miRNA表达异常能导致疾病甚至肿瘤的发生,有类似于抑癌基因或癌基因的功能.因此,对miRNA的进一步研究为肿瘤的诊断和治疗开辟了... |
| 关 键 词： | 肿瘤 微RNAs 基因表达调控 |
MicroRNA and human cancer |
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| REN Chang-zhen,CHEN Huan,JIAO Bing-hua. MicroRNA and human cancer[J]. Journal of International Oncology, 2011, 38(9): 649-652. DOI: 10.3760/cma.j.issn.1673-422X.2011.09.003 | |
| Authors: | REN Chang-zhen CHEN Huan JIAO Bing-hua |
| Abstract: | MicroRNA (miRNA) is a family of endogenous,non-coding small RNAs molecules that function as gene regulators.It has been revealed that miRNAs may play a critical role in many biological processes including cell proliferation,differentiation and apoptosis.Recent studies demonstrate that aberrant expression of miRNAs can lead to several human diseases even cancer.These tiny but potent molecules have the function as anti-oncogene or oncogene.Accordingly,further study of miRNAs has opened a novel avenue in the diagnosis and treatment of human cancer. |
| Keywords: | Neoplasms MicroRNAs Gene expression regulation |
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