外周T细胞淋巴瘤与自然杀伤细胞淋巴瘤

外周T细胞与自然杀伤(NK)细胞密切相关,并且具有部分相同的免疫表型和功能特性.外周T和NK细胞淋巴瘤异质性显著,分型复杂,目前大多尚未发现特有的分子表现.但随着分子技术的应用,对血管免疫母细胞T细胞淋巴瘤与辅助T细胞的相关性、间变性大细胞淋巴瘤的基因以及靶向治疗潜在标志物等有了进一步认识.

Peripheral T cell lymphoma and nature killer cell iymphoma

Peripheral T cells are closely related to nature killer( NK)cells,and share some immunophenotypic and functional properties with NK cells.Peripheral T-cell and NK cell lymphomas are heterogeneous groups of lymphomas,and the subgroup classification is complicated.Currently,the pathogenetic molecular lesions remain not to be deciphered for most entities.However,novel insights into the features of angioimmunoblastic T-cell lymphoma displaying correlation with normal helper T cells,the gene of anaplastic large cell lymphoma,and potential therapeutic biomarkers,have been gained from molecular technology application.