厄贝沙坦联合左旋氨氯地平治疗原发性高血压的疗效观察

目的观察厄贝沙坦联合左旋氨氯地平治疗原发性高血压的疗效和安全性。方法将180例原发性高血压患者随机分为观察组(厄贝沙坦联合左旋氨氯地平)和对照组(厄贝沙坦),各90例,均治疗8周。观察治疗前、后两组血压变化及不良反应发生情况。结果治疗后,两组收缩压(SBP)和舒张压(DBP)均明显下降(P<0.05);SBP在两组间比较差异有统计学意义(P<0.05),DBP在两组间比较差异无统计学意义(P>0.05)。观察组治疗后4、8周总有效率分别为88.2%和96.6%,对照组分别为75.5%和88.8%,两组总有效率比较差异有统计学意义(P<0.05)。观察组第8周总有效率明显高于第4周(P<0.05)。两组不良反应发生情况比较差异无统计学意义(P>0.05)。结论厄贝沙坦联合左旋氨氯地平具有良好的降压作用和较高的安全性。

Observation on efficacy and safety of irbesartan combined with levoamlodipine in treatment of primary hypertension

Objective To observe the clinical efficacy and safety of irbesartan combined with levoamlodipine in the treatment of primary hypertension.Methods 180 patients with primary hypertension were randomly assigned to the therapeutic group(irbesartan and levoamlodipine,n=93) and the control group(only irbesartan,n=93).Both groups were treated for 8 weeks.The changes of blood pressure and the occurrence of adverse reactions of two groups were observed before and after treatment.Results After treatment,systolic pressure and diastolic pressure of two groups were decreased significantly(P<0.05).The decrease of systolic pressure in the therapeutic group was significantly greater than that in the control group(P<0.05),but diastolic pressure showed no statistical difference.The total effective rates were 88.2% after 4 weeks and 96.6% after 8 weeks in the therapeutic group,and 75.5% and 88.8% in the control group respectively,showing statistical difference between two groups(P<0.05).Furthermore,the total effective rate of 8 weeks in the therapeutic group was higher than that of 4 weeks.There was no statistical difference of adverse reaction between two groups(P>0.05).Conclusion Irbesartan combined with levoamlodipine has good anti-hypertensive effect and high safety.