幽门螺杆菌相关上消化道疾病与复发性阿弗他溃疡相关性研究

目的探讨幽门螺杆菌（Helicobacter pylori，H．pylori）相关上消化道疾病与复发性阿弗他溃疡（recurrent aphthousulcer，RAU）的关系。方法运用聚合酶链反应技术和尿素酶试验对150例上消化道疾病患者的唾液和胃黏膜中的H．pylori检测，结合RAU的流行病学调查进行统计比较，并分析口腔和胃内H．pylori感染的相互影响及对龋齿的影响。结果胃黏膜H．pylori阳性患者中RAU的发病率为50．94％（27／53），明显高于阴性组13、40％（13／97）（P〈0．001）；口腔中H．pylori阳性和阴性两组患者的龋失补指数中位数分别为3．0和1．0，差异具有统计学意义（P〈0．05）；口腔中H．pylori阳性患者中RAU的发病率为24．72％（22／89），与阴性组29．51％（18／61）比较无明显差异（P〉0．05）；口腔内H．pylori感染与胃内H．pylori感染未见明显相关性（P〉0．05）。结论H．pylori相关上消化道疾病与RAU密切相关；口腔内H．pylori感染与龋齿发生有相关性。

Correlativity of Helicobacter pylori-associated disease of upper digestive tract and recurrent aphthous ulcer

Objective To investigate the relationship between H. pylori-associated disease of upper digestive tract and recurrent aphthous ulcer. Methods With the surveyed of RAU, the distribution of H. pylori in the saliva and gastric mueosa of 150 patients with disease of upper digestive traeted by polymerase chain reaction and rapid urease test were analyzed. The relationship between dental caries and patients whose saliva was H. pylori-positive was evaluated. Results The RAU rate in H. pylori-associated disease of upper digestive tract was 50.94% （27/53） , which was signifi- cantly higher than the H. pylori-negative 13.40% （13/97） ] （P 〈0. 001 ）. The RAU rate in patients whose saliva was H. pylori-positive was 24.72% （22/89） , which did not have obvious difference from H. pylori-negative 29.51% （18/ 61） ] （P 〉0.05）. The dental caries could be found obvious variance in the two groups（P 〈 0.05）; No significant difference was found between the H. pylori-positive rate in saliva and in gastric mucosa（P 〉 0.05 ）. Conclusion The results show that H. pylori-associated disease of upper digestive tract is closely involved in RAU and indicate that H. pylori in oral is related to dental caries.