心肌细胞外基质的改变与心力衰竭

1引言慢性充血性心力衰竭（congestiveheartfailure,CHF）是一组症候群,主要表现在心脏泵功能的进行性减退及心室腔的改建”·‘’。CHF可由多种心血管疾病引起。这些疾病包括缺血性心脏病、心肌肥大、瓣膜性心脏病和自发性心肌病等”－‘’。CHF时,除心肌细胞（mpocardialcells,MC）本身结构、代谢及功能异常外,心脏间质组织也发生异常改变”。上世纪80年代前对CHP的研究多集中在对MC本身的研究上。80年代以后,许多研究结果表明整个心脏泵功能的异常不仅仅取决于MC的改变。例如心肌肥大引起的心功能不全时,单个心肌细胞功能…

Role of extra cell matrix in the pathogenesis of heart failure

Cardiac extarellular matrix(ECM ) consists of several groups of extracellular macarelecules.In adultmyocardium, the major components of ECM includc collagen subtypes, fibronectin, laminin, metalloproteases(MMP), and tissue inhibitors of metalloproteases (TIMP). As a major component, cardiac collagen providesalignment to myocardial cells and serves as the skeleton of cardiac collagen network (CNW ), Which maintains theventricular chambers in normal structural architecture and function. Chronic congestive heart failure (CHF), anoutcome of a variety of cardiac diseases, is always associated with cardiac ECM remodeling including the changes ofcollagen synthesis, collagen deposition, acivation of MMP, and degradation of ECM. Those changes disrupt the cardiacCNW, which in turn causes the dilation of ventricular chambers, reduces the cardiac performance, and finallycontributes to the development of CHF.