| 糖尿病性心肌病变患者胰岛素强化治疗前后氧化应激水平的变化 |
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| 引用本文： | 黄海,宋成运,杜大勇,马建新,李运田,张世俊,许玉韵. 糖尿病性心肌病变患者胰岛素强化治疗前后氧化应激水平的变化[J]. 心脏杂志, 2012, 24(5): 606-608 |
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| 作者姓名： | 黄海 宋成运 杜大勇 马建新 李运田 张世俊 许玉韵 |
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| 作者单位： | (1.解放军第305医院心脏病中心，北京 100017； |
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| 摘 要： | 目的:评价糖尿病性心肌病(DCM)患者胰岛素泵强化治疗前后氧化应激水平的变化。方法: 30例DCM患者采用胰岛素泵强化治疗，治疗达标前后进行超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-PX）、丙二醛（MDA）水平测定并进行比较。结果: 胰岛素泵强化治疗后，患者血浆中的SOD、GSH-PX水平明显上升（P<0.01）、MDA水平明显下降（P<0.01）。空腹血糖、餐后2 h血糖、胰岛素抵抗指数、总胆固醇、三酰甘油、低密度脂蛋白、游离脂肪酸明显降低（P<0.05）,胰岛素分泌功能指数明显上升（P<0.05）。结论: DCM患者使用胰岛素泵强化治疗后氧化应激水平明显降低。
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| 关 键 词： | 心肌病，糖尿病性 胰岛素泵 氧化应激 |
| 收稿时间： | 2012-04-09 |
Effect of continuous subcutaneous insulin injection on oxidative stress level in patients with diabetic cardiomyopathy |
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| HUANG Hai,SONG Cheng-yun,DU Da-yong,MA Jian-xin,LI Yun-tian,ZHANG Shi-jun,XU Yu-yun. Effect of continuous subcutaneous insulin injection on oxidative stress level in patients with diabetic cardiomyopathy[J]. Chinese Heart Journal, 2012, 24(5): 606-608 |
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| Authors: | HUANG Hai SONG Cheng-yun DU Da-yong MA Jian-xin LI Yun-tian ZHANG Shi-jun XU Yu-yun |
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| Affiliation: | 1.Center of Cardiology,PLA 305 Hospital,Beijing 100017,China;2.Department of Cardiology,First Hospital,Peking University,Beijing 100034,China) |
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| Abstract: | AIM:To evaluate the effect of continuous subcutaneous insulin injection on oxidative stress level in patients with diabetic cardiomyopathy (DCM). METHODS: Thirty patients with DCM were treated with continuous subcutaneous insulin injection. SOD, GSH-PX and MDA were compared before and after insulin pump therapy. RESULTS: After treatment, SOD and GSH-PX levels significantly increased, whereas the MDA level significantly decreased (P<0.01). CONCLUSION: Oxidative stress level in DCM patients significantly decreases after continuous subcutaneous insulin injection treatment. |
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