地龙对小鼠血管紧张素转换酶活性的影响

目的：探讨地龙煎出液对小鼠血管紧张素转换酶（ACE）活性的影响。方法：取昆明种小鼠40只，随机分成四组，每组10只。空白组每天用生理盐水灌胃；对照组每天用福辛普利钠5．28mg／kg灌胃；地龙低剂量组每天20．0g／kg的地龙煎出液灌胃；地龙高剂量组每天40g／kg的地龙煎出液灌胃，连续灌胃7天。最后1次用药后2小时，小鼠眼眶取血，分离血清，按试剂盒说明书，分别测定ACE活性及血糖浓度。结果：地龙能显著降低小鼠ACE活性，降低幅度随浓度增高而增加，但对小鼠血糖浓度无影响。结论：地龙具有抑制ACE活性的作用。

Effect of Dilong on ACE Activity of Rats

Objective:To explore the effect of Dilong on ACE activeity of rats. Methods:30 Kunming rats were randomly divided into 4 groups with 10 rats each. The blank group and the contrast group were injected by saline and 5.28mg/kg fosinopril in stomach respectively each day. The low-dose Dilong group and the high-dose Dilong group were injected by 20g/kg and 40g/kg Dilong decoction respectively each day. All rats were injected by 7 days. The blood was taken out from the eyepit of rats and serum separated 2 hours after the last injection. The activity of ACE and the thickness of blood sugar were measured according to the demonstrative note of reagents. Results:Dilong could decrease the activity of ACE. The decreasing degree would be improved with the increasing thickness of Dilong decoction. However Dilong had no effect on the thickness of blood sugar. Conclusion:Dilong has restrainable effect on activity of ACE.