宫颈癌相关显著突变基因研究进展

宫颈癌是最常见的妇科恶性肿瘤,在发展中国家,宫颈癌的发病率与死亡率常年居高不下,虽然关于宫颈癌的研究已广泛开展,但其具体发生机制及协同因素至今尚未阐明.近年来,基因突变与宫颈癌的关系逐渐受到重视.众多研究表明,癌基因、抑癌基因及相关调节基因的改变与宫颈癌发生及病情的进展密切相关.随着基因组测序技术在恶性肿瘤中的应用,更...

Research Progress on Cervical Cancer Related Significantly Mutated Genes

Cervical cancer is the most common gynecological malignant tumor. In developing countries, the incidence and mortality of cervical cancer are always high. Although the research on cervical cancer has been widely carried out, its specific mechanism and synergistic factors have not yet been elucidated. In recent years, more and more attention has been paid to the relationship between gene mutations and cervical cancer. Numerous studies have shown that changes in oncogenes, tumor suppressor genes and related regulatory genes are closely related to the development of cervical cancer and the progression of the disease. With the application of genome sequencing technology in cancer, more gene mutations are found in cervical cancer, and the identification of significant mutations can help further lock cancer-driven genes, so significant mutations may be the key to discover the underlying mechanisms of cancer. This overview of recent research status of the newly discovered significant mutations Erb B-3, HLA-A,CASP8 and TGFBR2 in cervical cancer may provide new ideas for the mechanism research, diagnosis and targeted therapy of cervical cancer.