乳杆菌属防治急性放射性肠损伤的研究进展

急性放射性肠损伤是腹盆腔放疗患者常见并发症,然而目前没有有效的临床防治手段。作为益生菌和肠道共生菌的乳杆菌属对肠道健康有诸多益处。临床前研究发现乳杆菌属可以防治急性放射性肠损伤,其机制为保护肠隐窝干细胞、维持肠道屏障及抗氧化等。临床研究提示放疗前1周开始口服足量含乳杆菌属的复合益生菌有助于预防放疗导致的腹泻,并且口服乳杆菌属有治疗放疗后腹泻及减轻放射性直肠炎的趋势,目前没有相关不良反应的报道。

Research progress on the prevention and treatment of radiation-induced intestinal injury by the genus Lactobacillus

Acute radiation-induced intestinal injury is the common complication in patients following abdominal and pelvic radiotherapy. However, no effective clinical prevention and treatment interventions are available. As the probiotics and symbiotic bacteria, many species of the genus Lactobacillus are normally present in the gastrointestinal tract and beneficial for the intestinal health. Preclinical studies have reported that the genus Lactobacillus can prevent and treat acute radiation-induced intestinal injury by protecting crypt stem cells,maintaining intestinal barrier and exerting the antioxidant effect, etc. Clinical trials have prompted that oral administration of adequate complex probiotics containing Lactobacillus spp.at one week before radiotherapy contributes to preventing radiation-induced diarrhea. In addition, oral intake of the genus Lactobacillus has the tendency to treat radiation-induced diarrhea and mitigate acute radiation proctitis. At present,no relevant adverse events have been reported.