| 放疗联合免疫检查点抑制剂治疗非小细胞肺癌研究进展 |
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| 引用本文： | 金佳男,徐裕金,陈梦圆,陈明.放疗联合免疫检查点抑制剂治疗非小细胞肺癌研究进展[J].中华放射肿瘤学杂志,2020,29(6):477-481. |
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| 作者姓名： | 金佳男 徐裕金 陈梦圆 陈明 |
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| 作者单位： | 浙江中医药大学第二临床医学院,杭州 310053;中国科学院肿瘤与基础医学研究所,中国科学院大学附属肿瘤医院/浙江省肿瘤医院胸部放疗科,杭州 310022 |
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| 摘 要： | 免疫检查点抑制剂(ICI)的出现为非小细胞肺癌的治疗提供了新方法。而单用ICI的局限性促使临床医生开始探索放疗联合ICI的可行性。近期有关联合治疗的各项研究已初步揭示了其改变非小细胞肺癌治疗体系的巨大前景。本文从联合治疗的机制出发,综述有关联合治疗的基础研究和不同放疗方式联合ICI的临床进展。
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| 关 键 词： | 肺肿瘤/放射治疗 肺肿瘤/免疫治疗 免疫检查点抑制剂 研究进展 |
| 收稿时间： | 2019-01-06 |
Research progress on radiotherapy combined with immune checkpoint inhibitor in the treatment of non-small cell lung cancer |
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| Jin Jianan,Xu Yujin,Chen Mengyuan,Chen Ming.Research progress on radiotherapy combined with immune checkpoint inhibitor in the treatment of non-small cell lung cancer[J].Chinese Journal of Radiation Oncology,2020,29(6):477-481. |
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| Authors: | Jin Jianan Xu Yujin Chen Mengyuan Chen Ming |
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| Institution: | The Second Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou 310053, China;Department of Cancer andBasic Medicine, Chinese Academy of Sciences;Department of Radiation Oncology, Cancer Hospital of the University of Chinese Academy of Sciences/Zhejiang Cancer Hospital, Hangzhou 310022, China |
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| Abstract: | The emergence of immune checkpoint inhibitors (ICI) provides a novel method for the treatment of non-small cell lung cancer (NSCLC). However, the limitation of ICI alone prompts clinicians to explore the feasibility of radiotherapy combined with ICI. Recent studies on this combined therapy have preliminarily revealed its significant prospects for changing the treatment system of NSCLC. From the perspective of the mechanism of combined therapy, this study reviewed the basic research on this combined therapy and the clinical progress on different radiotherapy combined with ICI. |
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| Keywords: | Lung neoplasm/radiotherapy Lung neoplasm/immunotherapy Immune checkpoint inhibitor Research progress |
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