细胞因子与细胞因子风暴

摘要：细胞因子是一类能在细胞间传递信息、具有免疫调节和效应功能的低分子质量蛋白或多肽，通过调节免 疫反应的强度和持续时间在免疫系统中起重要作用。在感染期间通过免疫细胞产生细胞因子引发炎症反应，对于 早期清除病原体至关重要。然而，细胞因子在高炎症状态下被过度分泌释放可能会引发患者体内发生“细胞因子风 暴”（高细胞因子血症）的现象，从而在组织和关键器官内产生无节制的炎症。细胞因子风暴与流感、败血症/败血性 休克、急性呼吸窘迫综合征等密切相关，最终导致多器官功能衰竭。本文概述了细胞因子的分类及生物学功能、细 胞因子风暴的临床及损伤机制、新型冠状病毒（SARS-CoV-2）诱发细胞因子风暴的治疗等方面的研究进展，为细胞 因子风暴综合征的防治提供指导

Cytokine and cytokine storm #br#

Abstract: Cytokines are a diverse group of small molecule proteins or peptides that are secreted by cells for the purpose of intercellular delivery signaling and communication, which play an important role in the immune system by regulating both the intensity and duration of the immune response. During infection, the triggering of the inflammatory response, especially through the production of cytokines, is essential for the early elimination of pathogens. However, cytokines are intense secreted and released during a hyperinflammatory state that may trigger a dangerous condition known as "cytokine storm" (or hypercytokinemia), resulting in uncontrolled inflammation in tissues and key organs. Cytokine storms are closely related to influenza, sepsis/septic shock and acute respiratory distress syndrome, which ultimately lead to multiple organ failure. This review outlines the classification and biological functions of cytokines, the clinic and damage mechanism of cytokine storms, and treatment of novel coronavirus (SARS-CoV-2), which provides guidance for the prevention and treatment of cytokine storm syndrome