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| 针刺对哮喘豚鼠肺内嗜酸细胞凋亡及Fas表达的影响 | |
| 引用本文： | 刘鑫,戴爱国,周继鹏,周金桔,赵强,樊天会.针刺对哮喘豚鼠肺内嗜酸细胞凋亡及Fas表达的影响[J].上海针灸杂志,2003,22(7):3-5. |
| 作者姓名： | 刘鑫 戴爱国 周继鹏 周金桔 赵强 樊天会 |
| 作者单位： | 1. 南华大学附属第一医院,湖南衡阳,421001 2. 南华大学附属第三医院,湖南衡阳,421000 3. 衡南县第二人民医院,湖南,421100 |
| 基金项目： | 湖南省教育厅基金资助 ( 0 1C181) |
| 摘 要： | 目的 观察针刺定喘、膏肓、肺俞、丰隆等穴对哮喘豚鼠嗜酸粒细胞(EOS)凋亡及Fas表达的影响。方法 将27只豚鼠随机分成3组，哮喘模型组、针刺组和空白组。造模同时分别针刺，2w后，心脏采血并取肺组织，HE染色，以TUNEL法观测肺内EOS凋亡，以免疫组化观测Fas抗原表达。结果 空白组、模型组少见EOS凋亡及FAS阳性表达，而针刺组见EOS凋亡，有较多的FAS抗原阳性表达的细胞。结论 针刺可诱导哮喘豚鼠的肺内EOS凋亡。 |
| 关 键 词： | 哮喘 针刺疗法 嗜酸粒细胞 细胞凋亡 Fas抗原 |
| 文章编号： | 1005-0957(2003)07-0003-03 |
| 修稿时间： | 2003年3月9日 |
Effect of Acupuncture on Apoptosis of Pulmonary Eosinophile in Asthmatic Guinea-pigs |
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| LIU Xin ,DAI Ai guo ,ZHOU Ji peng ,ZHOU Jin ju ,ZHAO Qiang ,FAN Tian hui ..Effect of Acupuncture on Apoptosis of Pulmonary Eosinophile in Asthmatic Guinea-pigs[J].Shanghai Journal of Acupuncture and Moxibustion,2003,22(7):3-5. | |
| Authors: | LIU Xin DAI Ai guo ZHOU Ji peng ZHOU Jin ju ZHAO Qiang FAN Tian hui |
| Institution: | LIU Xin 1,DAI Ai guo 2,ZHOU Ji peng 1,ZHOU Jin ju 3,ZHAO Qiang 1,FAN Tian hui 1. 1.The First Hospital Affiliated to Nanhua University,Hengyang 421001,China, 2.The Third Hospital Affiliated to Nanhua University,Hengyang 421000,China, 3.The Second People's Hospital of Hengnan county,Hunan 421100,China) |
| Abstract: | Objective To explore the effect and Acupuncture on Apoptosis of pulmonary eosinphiles (PE) in asthmatic guinea pigs. Methods twenty seven guinea pigs were divided into 3 groups at random, an asthma model group, an acupuncture group and an control group. PE apoptosis were observed by TdT mediated duTp nick end labeling technique and the expression of Fas, by immunohistochemistry. Results In the asthmatic group, the amount of infiltrating PE increased and Peapoptotic index decreased significantly .In the Acupuncture group the two parameters changed significantly ( P <0.05). Conclusion Acupuncture can inhibit PE apoptosis. |
| Keywords: | Asthma Eosinophils Cell death Acupuncture therapy |
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