Rapid T cell receptor-mediated SHP-1 S591 phosphorylation regulates SHP-1 cellular localization and phosphatase activity |
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| Authors: | Liu Yin Kruhlak Michael J Hao Jian-Jiang Shaw Stephen |
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| Affiliation: | Experimental Immunology Branch, Bldg. 10/4B05 National Cancer Institute, NIH Bethesda, MD 20892, USA. |
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| Abstract: | Since the tyrosine phosphatase SHP-1 plays a major role in regulating T cell signaling, we investigated regulation thereof by Ser/Thr phosphorylation. We found that T cell receptor (TCR) stimulation induced fast (
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