| 冠心病患者炎症反应与内皮功能损伤的关系 |
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| 引用本文： | 杨海玉,曾玉杰,苗立夫,黄占军.冠心病患者炎症反应与内皮功能损伤的关系[J].医学理论与实践,2002,15(7):747-748. |
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| 作者姓名： | 杨海玉 曾玉杰 苗立夫 黄占军 |
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| 作者单位： | 1. 广东省江门市中心医院心内科,529071
2. 华中科技大学附属同济医学院心血管病研究所,武汉 |
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| 摘 要： | 目的:探讨C-反应蛋白,纤维蛋白原及血管假性血友病因子间的关系。方法:检测急性心肌梗死(AMI)组,心绞痛(AP)组,正常对照(CTL)组各30例的血清C-反应蛋白、纤维蛋白原、血管假性血友病因子水平。结果:AMI组的血C-反应蛋白,纤维蛋白原、血管假性血友病因子均高于AP组和CTL组(P值均<0.05)。AP组3个指标高于CTL组(P值均<0.05)。C-反应蛋白、纤维蛋白原、血管假性血友病因子浓度间彼此正直线相关(P值均<0.01)。结论:①C-反应蛋白、纤维蛋白原在冠心病发生、发展中起重要作用。②炎症反应通过损伤内皮细胞的功能而起作用,并与冠心病的严重程度有关。
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| 关 键 词： | C-反应蛋白 纤维蛋白原 血管假性血友病因子 心绞痛 急性心肌梗死 |
| 修稿时间： | 2002年2月10日 |
The Relationship between Inflammation and Endothelia Dysfunction Patients with Coronary Heart Disease |
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| YANG Haiyu,ZENG Yujie,MIAO Lifti,HUANG Zhanjun,The Central Hospital of Jiangmen,Guangdong , The Institute of Cardiovascular System Diseases,Tongji Medical College,Huazhong University of Science and Technology,Wuhan.The Relationship between Inflammation and Endothelia Dysfunction Patients with Coronary Heart Disease[J].The Journal of Medical Theory and Practice,2002,15(7):747-748. |
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| Authors: | YANG Haiyu ZENG Yujie MIAO Lifti HUANG Zhanjun The Central Hospital of Jiangmen Guangdong The Institute of Cardiovascular System Diseases Tongji Medical College Huazhong University of Science and Technology Wuhan |
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| Institution: | YANG Haiyu,ZENG Yujie,MIAO Lifti,HUANG Zhanjun,The Central Hospital of Jiangmen,Guangdong 529071, The Institute of Cardiovascular System Diseases,Tongji Medical College,Huazhong University of Science and Technology,Wuhan |
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| Abstract: | Objective:To study the relationship between inflammation and endothelia dysfunction in patients with coronary heart disease.Methods:Blood samples were collected from 30 acute myocardial infarction patients,30 angina pectoris and 30 healthy control subjects.Serum C-reactive protein (CRP)and plasma fibrinogen (Fg)were analyzed by immunonephelometry,von Willebrand factor (VWF) was determined by enzyme-linked immunoadsorbent assay(ELISA) .Results:The levels of CRP,Fg VWF in acute myocardial infarction patients were higher than in angina pectoris patients (all P < 0.01) ,the levels of the three factors in angina pectoris patients were higher than in control group ( P < 0.01), and positively correlated to each other (all P < 0.01). Conclusion: Inflammatory acute phase protein maybe play an important role in atherosclerosis by impaired endothelial function. The severity of coronary heart disease was determined by levels of inflammatory markers. |
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| Keywords: | C-reactive protein Fibrinogen Von willebrand factor Angina pectoris Acute myocardial infarction |
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