银杏叶片联合阿魏酸钠治疗短暂性脑缺血发作的临床研究

目的探讨银杏叶片联合阿魏酸钠治疗短暂性脑缺血发作的临床疗效。方法选取2015年3月—2016年3月在日照市人民医院接受治疗的短暂性脑缺血发作患者78例,按照治疗方法的不同分为对照组和治疗组,每组各39例。对照组静脉滴注注射用阿魏酸钠,0.3 g加入5%葡萄糖注射液250 m L,1次/d。治疗组在对照治疗基础上口服银杏叶片,2片/次,3次/d。两组均连续治疗2周。观察两组的临床疗效,同时比较两组治疗前后血浆黏度(CP)、血细胞比容(HCT)、血小板聚集率(PAR)、纤维蛋白原(FIB)、内皮素-1(ET-1)、基质金属蛋白酶-9(MMP-9)、血管紧张素-II(Ang-II)的变化情况。结果治疗后,对照组和治疗组的总有效率分别为84.62%、92.31%,两组比较差异有统计学意义(P0.05)。治疗后,两组患者CP、HCT、PAR、FIB、ET-1、MMP-9、Ang-II均较同组治疗前显著降低,同组治疗前后差异均有统计学意义(P0.05),且治疗组这些观察指标的降低程度优于对照组,两组比较差异具有统计学意义(P0.05)。结论银杏叶片联合阿魏酸钠治疗短暂性脑缺血发作具有较好的临床疗效,可明显改善患者血液流变学指标,降低血清ET-1、MMP-9、Ang-II水平,具有一定的临床推广应用价值。

Clinical study on Yinxingye Tablets combined with sodium ferulate in treatment of transient ischemic attack

Objective To explore the clinical efficacy of Yinxingye Tablets combined with sodium ferulate in treatment of transient ischemic attack. Methods Patients (78 cases) with transient ischemic attack in Rizhao People’s Hospital from March 2015 to March 2016 were enrolled in this study. According to the different treatment plans, patients were divided into control group (39 cases) and treatment group (39 cases). The patients in the control group were iv administered with Sodium Ferulate for injection, 0.3 g added into 5% Glucose Injection 250 mL, once daily. The patients in the treatment group were po administered with Yinxingye Tablets on the basis of the control group, 2 tablets/time, three times daily. The patients in two groups were treated for 2 weeks. After treatment, the clinical efficacies were evaluated, and the changes of CP, HCT, PAR, FIB, ET-1, MMP-9, and Ang-II in two groups before and after treatment were compared. Results After treatment, the total efficacies in the control and treatment groups were 84.62% and 92.31%, respectively, and there were differences between two groups (P < 0.05). After treatment, CP, HCT, PAR, FIB, ET-1, MMP-9, and Ang-II in two groups were significantly decreased, the difference was statistically significant in the same group (P < 0.05). After treatment, the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Yinxingye Tablets combined with sodium ferulate has clinical curative effect in treatment of transient ischemic attack, and can obviously improve the blood rheology indexes, reduce the levels of ET-1, MMP-9, and Ang II, which has a certain clinical application value.