Agaricus brasiliensis mycelium supplementation in Sarcoma 180tumour-bearing mice reverses the immune response induced by the tumour |
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| Authors: | Herta S. Dalla-Santa Rosália Rubel Francisco M.D. Vitola Dorli Buchi Raffaello P. Di-Bernardi Andréa N. Moreno |
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| Affiliation: | 1. Department of Food Engineering , Midwest State University (UNICENTRO) , Sime?o de Camargo Varela de Sá, 03, CEP 85040-080 , Guarapuava , Paraná , Brazil;2. Division of Bioprocess Engineering and Biotechnology , Federal University of Paraná (UFPR) , Jardim das Américas, CEP 81531-990 , Curitiba , Paraná , Brazil;3. Department of Cellular Biology , Federal University of Paraná (UFPR) , Jardim das Américas, CEP 81531-990 , Curitiba , Paraná , Brazil;4. Laboratory of Agricultural and Livestock Technology , Pontifical Catholic University of Paraná , 16 BR 376 Km 14, CEP 83010-500 , S?o José dos Pinhais , Paraná , Brazil |
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| Abstract: | The biological properties of Agaricus brasiliensis mycelium, including their immuno-stimulating and anti-tumour activities, have previously been investigated. The aim of this study was to evaluate the effects of long-term intake of A. brasiliensis mycelium cultivated on wheat grains by solid-state culture on tumour growth and immune response in Sarcoma 180 tumour-bearing mice. Mice received dietary supplementation with 100% or 50% Agaricus mycelium cultivated on wheat grains for 14 weeks and were inoculated with Sarcoma 180 tumours. We found that A. brasiliensis had anti-tumour activity, and that dietary supplementation with a 50% concentration (A50S) prevented loss of body weight, inhibited tumour growth, induced the increase of CD4+ T cells and CD25+ CD4+ T subsets in peripheral organs and downregulated Tumor necrosis factor alpha production in plasma. Our results confirm that dietary supplementation with Agaricus may offer immuno-modulatory activity and protection against tumour growth. |
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| Keywords: | Agaricus brasiliensis anti-cancer activity edible mushroom mice |
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