上皮性卵巢癌患者手术及化疗前后血清中人附睾蛋白4和糖类抗原125的变化

目的探讨上皮性卵巢癌患者手术及化疗前后血清中人附睾蛋白4(HE4)和糖类抗原125(CA125)的变化。方法选取2012年3月至2013年3月间收治的50例上皮性卵巢癌患者,采用酶联免疫吸附试验(ELISA)检测50例上皮性卵巢癌患者(研究组)手术及化疗前后、正常健康人群(健康组)及卵巢良性肿瘤患者(对照组)血清中HE4和CA125水平,探讨其在疾病预后的的价值。结果对照组患者CA125和HE4水平显著高于健康组,差异有统计学意义(P<0.05)。研究组患者术前CA125和HE4水平明显高于对照组和健康组,其中化疗3个疗程后血清CA125水平降至正常水平,化疗2个疗程后血清HE4水平降至正常水平。CA125阴转符合率为41.5%,HE4阴转符合率为75.6%,CA125+HE4联合检测阴转符合率则增至85.4%;联合检测阳转符合率高达100%。结论血清CA125和HE4联合检测对卵巢癌预后判断有重要指导意义,可作为卵巢癌病情检测指标之一。

The changes of serum HE4 and CA125 in epithelial ovarian cancer patients before and after opera- tion and chemotherapy

Objective To explore the changes of serum HE4 and CA125 in epithelial ovarian cancer patients before and after operation and chemotherapy. Methods 50 cases of epithelial ovarian cancer patients sleeted from 2012 March to 2013 in Affiliated Tumor Hospital of Xinjiang Medical University, by used using enzyme linked immunosorbent assay （ELISA） detected serum HE4 and CA125 levels of normal healthy people, benign ovarian tumor patientsand 50 cases of patients with epithelial ovarian cancer operation and chemotherapy, and studied its prognosis value. Results Control group CA125 and HE4 were sig- nificantly higher than healthy group, the difference was statistically significant between the two groups （ P 〈 0. 05）;The study group; preoperative CA125, HE4 concentration was significantly higher than that of the control group; the serum CA125 concentration decreased to normal level after 3 courses of chemotherapy, the serum HE4 concentration decreased to normal level after 2 courses of chemotherapy. CA125 negative co- incidence rate was 41.46% , HFA 75.61% , CA125 ＋ HE4 joint detection negative coincidence rate increased to 85.37% ; the combined detection of seroeonversion rate as high as 100%. Conclusion The combined detection of serum CA125, HE4 has an important significance to the prognosis of ovarian cancer, can be used as one of the ovarian cancer detection index.