IL-6-572基因多态性与侵袭性牙周炎易感性的相关性研究

目的 研究白细胞介素-6(interleukin-6,IL-6)-572位点基因多态性与侵袭性牙周炎易感性的关系.方法 采用病例对照试验设计,从广东汉族人群中选择83例侵袭性牙周炎(aggressive periodontitis,AgP)患者(AgP组)及79例牙周健康者(对照组),采用聚合酶链反应—限制性内切酶片段长度多态性分析方法对IL-6-572位点基因多态性进行检测,分析组间基因型频率及等位基因分布的差异.结果 IL-6基因启动子区-572位点G/C基因型在AgP组、对照组中的分布频率差异有统计学意义(x2=13.710,P=0.001).AgP组与对照组相比,G、C等位基因频率分布差异有统计学意义(x2=13.213,P<0.001),G等位基因相对于C等位基因:OR值为2.988,95%CI:1.634~5.465.结论 IL-6-572 G/C位点的基因多态性同中国广东汉族人群侵袭性牙周炎患病易感性可能存在相关关系,IL-6-572 G等位基因可能是广东汉族人群AgP遗传易感性的高风险因素.

Relationship between interleukin-6 -572 gene polymorphism and aggressive periodontitis in Chinese

Objective To investigate the association between interleukin-6-572 gene polymorphism and aggressive periodontitis. Methods A case-control study involved 83 patients with aggressive periodontitis (AgP) and 69 health con-trols was held, and the genotype and allele distributions of interleukin-6-572 gene polymorphism were analyzed by PCR-RFLP. Results There was statistically significant differences in the genotype distribution by the chi-square test in the two groups (x2=13.710, P=0.001). The distribution of allele frequencies in AgP group was statistically different (x2=13.213, P<0.001) from the healthy control group, and the OR for the G allele is 2.988 (95%CI:1.634-5.465) when com-pared with the C allele. Conclusion IL-6 -572 gene polymorphism is associated with the susceptibility to AgP in Chi-nese Han population of Guangdong, and the IL-6-572 G allele might be a risk factor of the genetic susceptibility to AgP.