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| 纳米混悬剂的物理稳定性研究进展 | |
| 引用本文： | 谢向阳,陈晨,廖祥茹,韩亮. 纳米混悬剂的物理稳定性研究进展[J]. 国际药学研究杂志, 2011, 38(5): 369-374 |
| 作者姓名： | 谢向阳 陈晨 廖祥茹 韩亮 |
| 作者单位： | 广州军区武汉总医院药剂科,武汉,430070 |
| 基金项目： | 广州军区武汉总医院青年基金 |
| 摘 要： | 纳米混悬剂具有增加药物溶解度,提高生物利用度,降低毒副作用等特点,有关这方面的研究是目前纳米制剂研究的一个热点,美国FDA至今已批准多个相关产品上市.物理稳定性问题在纳米药物混悬液中比较突出,是制约纳米混悬液研发的重要因素之一.本文就纳米混悬剂物理稳定性所面临的问题、理论机制及其应对策略进行综述. |
| 关 键 词： | 纳米混悬剂 物理稳定性 稳定剂 |
| 收稿时间： | 2011-05-24 |
| 修稿时间： | 2011-07-26 |
Physical stability of nanosuspensions:research advances |
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| XIE Xiang-yang,CHEN Chen,LIAO Xiang-ru,HAN Liang. Physical stability of nanosuspensions:research advances[J]. Foreign Medical Sciences(Section of Pharmarcy), 2011, 38(5): 369-374 | |
| Authors: | XIE Xiang-yang CHEN Chen LIAO Xiang-ru HAN Liang |
| Affiliation: | (Department of Pharmacy, Wuhan General Hospital of Guangzhou Military Command, Wuhan 430070, China) |
| Abstract: | Nanosuspensions have characteristics of increasing solubility, improving bioavailability, reducing toxicity of drugs, and have become a hotspot in the research area of nanodrugs recently. A few related drugs of nanosuspensions were approved by the FDA of USA up to date. Physical stability is a key issue that limits the research and development of naosuspensions. This article reviews the physical stability of nanosuspensions, including their mechanisms and corresponding strategies to overcome the stability problems. |
| Keywords: | nanosuspensions physical stability stabilizers |
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