Effect of bisphosphonates on ankylosing spondylitis: A meta-analysis |
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| Affiliation: | 1. Department of Orthopaedic Surgery, Good Samsun Hospital, Busan, Republic of Korea;2. Department of Orthopaedic Surgery, Gupo Sungshim Hospital, Busan, Republic of Korea;3. Department of Orthopaedic Surgery, Biomedical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Republic of Korea;4. Department of Orthopaedic Surgery, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea;1. Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA;2. Department of Neurosurgery, Mayo Clinic, Rochester, MN 55905, USA;3. Department of Neurosurgery, Zucker School of Medicine at Hofstra, Long Island Jewish Medical Center and North Shore University Hospital, Northwell Health, Manhasset, NY 11030, USA;1. The Warren Alpert School of Medicine, Brown University, Providence, RI, United States;2. Department of Neurosurgery, Rush University Medical Center, Chicago, IL, United States;3. Department of Neurosurgery, Rhode Island Hospital, Providence, RI, United States;4. Department of Neurosurgery, Southcoast Brain & Spine, North Dartmouth, MA, United States;1. Department of Neurology, AIIMS, Rishikesh, Uttarakhand, India;2. Ex-HOD, Department of Neurology, Sanjay Gandhi PGIMS, Lucknow 226014, Uttar Pradesh, India;3. Apollo Medics Super-specialty Hospitals and Senior Consultant Neurologist, Vivekanand Polyclinic, and Institute of Medical Science, Lucknow 22600, India;1. Department of Biotechnological and Applied Clinical Science, University of L’Aquila AQ, Via Vetoio 1 AQ, 67100, Italy;2. Neurology Unit, San Salvatore Hospital, L''Aquila, Italy;3. Department of Life, Health and Environmental Sciences, University of L’Aquila, Italy;4. Department of Neurosurgery, University of L’Aquila AQ, Via Vetoio 1 AQ, 67100, Italy;1. Neurology Department, Vall d’Hebron Universitary Hospital, Barcelona, Spain;2. Cooper Medical School of Rowan University, Camden, USA |
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| Abstract: | This study aimed to compare outcomes between ankylosing spondylitis (AS) treated with and without bisphosphonate (BP; non-BP) through a meta-analysis. The Medline (via PubMed), Cochrane, Scopus, and Embase databases were searched for studies that evaluated the outcomes of AS, including patient age, disease duration, disease activity, and bone mineral density (BMD), published between January 2000 and March 2020. Two authors extracted the data independently. Any discrepancies were resolved by a consensus. Six comparative studies were identified. No significant differences were found between the BP and non-BP groups in terms of demographic characteristics, disease activity, and BMD, except for follow-up erythrocyte sedimentation rate (ESR). The follow-up ESR was higher in the BP than in the non-BP group. A literature review identified six comparative studies reporting the outcomes of BP and non-BP treatments for AS. Despite the heterogeneity, a limited number of meta-analyses reported that BP treatment was not clearly better than non-BP treatment. Hence, further large-scale multicenter studies are required to validate our results. |
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| Keywords: | Bisphosphonate Ankylosing spondylitis Meta-analysis |
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