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| 胰岛素样生长因子Ⅱ受体在卵巢癌细胞株中的表达及全反式维甲酸对其表达的影响 | |
| 引用本文： | 尹德领,步世忠,裴钢,施瑾. 胰岛素样生长因子Ⅱ受体在卵巢癌细胞株中的表达及全反式维甲酸对其表达的影响[J]. 现代妇产科进展, 1997, 0(2) |
| 作者姓名： | 尹德领 步世忠 裴钢 施瑾 |
| 作者单位： | 中国科学院上海细胞生物学研究所，上海市第一人民医院 |
| 摘 要： | 目的：探讨胰岛素样生长因子Ⅱ受体在卵巢癌细胞中的表达以及全反式维甲酸对其的影响。方法：应用ＮｏｒｔｈｅｒｎＢｌｏｔ技术检测卵巢癌细胞株３Ａｏ，Ａｏ有无胰岛素样生长因子Ⅱ受体以及全反式维甲酸对其的影响。结果：卵巢癌Ａｏ细胞株高表达胰岛素样生长因子Ⅱ受体，３Ａｏ细胞则较低。全反式维甲酸明显引起Ａｏ细胞胰岛素样生长因子Ⅱ受体下降，而３Ａｏ细胞差异不明显。结论：卵巢癌细胞株３Ａｏ和Ａｏ均表达胰岛素样生长因子Ⅱ受体，全反式维甲酸引起Ａｏ细胞株胰岛素样生长因子受体下降，提示胰岛素样生长因子Ⅱ受体参与了全反式维甲酸诱导卵巢癌Ａｏ细胞凋亡过程。 |
| 关 键 词： | 胰岛素样生长因子Ⅱ受体；卵巢肿瘤；全反式维甲酸；Northern印迹杂交 |
Changes of insulin like growth factor Ⅱ receptor expression in ovarian cancer cell lines by all transretinonic acid. |
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| Yin Deling,Bu Shizhong,Pei Gang,et al. Changes of insulin like growth factor Ⅱ receptor expression in ovarian cancer cell lines by all transretinonic acid.[J]. Current Advances In Obstetrics and Gynecology, 1997, 0(2) | |
| Authors: | Yin Deling Bu Shizhong Pei Gang et al |
| Abstract: | Objective To investigate the changes of insulin like growth factor Ⅱ receptor expression in ovarian cancer cell lines by all transretinonic acid. Methods The expression of insulin like growth factor Ⅱ receptors was tested by using the northern blot analysis. Results The expressions of insulin like growth factor Ⅱ receptors were detected by northern blot analysis in both 3AO and AO ovarian cancer cells.After exposed to all transretinonic acid for 48 hours,the levels of insulin like growth factor Ⅱ receptors were remarkedly decreased in AO cells.No significant change in expression of insulin like growth factor Ⅱ receptor was detected in 3AO cells. Conclusions All transretinonic acid could diminish the expression of insulin like growth factor Ⅱ receptors in AO cells.This may indicate involvement of insulin like growth factor Ⅱ receptor in all transretinonic acid induced apoptosis in AO cells. |
| Keywords: | Insulin like growth factor Ⅱ receptors Ovarian neoplasms,All transretinonic acid Northern blot analysis |
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