| 高尔基体蛋白73对中国人群肝癌诊价值的Meta分析 |
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| 引用本文： | 张国明,;夏永杰,;李业成.高尔基体蛋白73对中国人群肝癌诊价值的Meta分析[J].陕西医学检验,2014(3):78-80. |
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| 作者姓名： | 张国明 ;夏永杰 ;李业成 |
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| 作者单位： | [1]沭阳县人民医院,江苏宿迁223600; [2]复旦大学公共卫生学院,上海200032 |
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| 摘 要： | 目的 评价高尔基体蛋白73（golgi protein 73,GP73）检测在肝癌诊断中的价值.方法 检索万方、中国知网、NCBI PubmMed,EMBSASE数据库中2000-2013年符合纳入标准的国内外公开发表的有关以血清GP73诊断中国人肝癌的文献8篇,采用meta-disc1.4软件进行统计软件分析.结果 GP73诊断肝癌敏感度为78％,95％可信区间为0.74-0.81;特异度为75％,95％可信区间为0.73-0.78;阳性预测值为5.07,95％可信区间为2.95-8.72;阴性预测值为0.29,95％可信区间为0.23-0.37;诊断优势比为18.98,95％可信区间为8.46-42.54;综合SROC曲线下面积（AUC）为0.86,Q值为0.79.结论 GP73作为肝癌肿瘤标志物在肝癌的诊断中有一定价值.
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| 关 键 词： | 肝肿瘤 高尔基体蛋白73(GP73) |
Meta-Analysis of Diagnostic Vabue of GP73for the Hepatocellular Carcinoma in China |
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| Institution: | ZHANG Guo-ming,XIA Yong-jie,LI Ye-cheng( 1.Shuyang People＇s Hospital, Jiangsu Suqian 223600, China; 2.School of Public Health in Fudan University, Shanghai 200032, China) |
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| Abstract: | Objective To evaluate the diagnostic value of serum GP73 levels in HCC diagnosis.Methods Retrieve Articles,China Knowledge Network,NCBI PubmMed,EMBSASE database 2000-2013 years met the inclusion criteria published a broad in relation to serum GP73 diagnosis China＇s eight cases of human hepatocellular carcinoma literature,through a com prehensive analysis of the random effects model effect size,the use of meta disc1.4 software for statistical analysis software.The Results GP73 diagnosis ofliver cancer sensitivity was 78％,95 ％ confidence interval 0.74-0.81,and specificity was 75 ％,95 ％ confidence interval 0.73 -0.78.Positive predictive value was 5.07,95 ％ CI 2.95 - 8.72,and negative predictive value was 0.29,95％ confidence interval 0.23-0.37.Diagnostic odds ratio was 18.98,95％ CI 8.46-42.54,and SROC in tegrated area under the curve （AUC） was 0.86,Q=0.79.Conclusion GP73 as liver cancer tumor markers in the diagnosis of liver cancer have a certain value. |
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| Keywords: | liver tumors golgi protein 73 （GP73） |
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