| Fas配体在大肠腺瘤、大肠癌及肝转移中的表达和意义 |
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| 引用本文： | 张伟,丁尔迅,王强,李玉莉,何金. Fas配体在大肠腺瘤、大肠癌及肝转移中的表达和意义[J]. 中国肿瘤临床, 2004, 31(1): 12-14 |
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| 作者姓名： | 张伟 丁尔迅 王强 李玉莉 何金 |
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| 作者单位： | 1. 第二军医大学长征医院普外科,上海市,200003
2. 第二军医大学长征医院病理科,上海市,200003 |
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| 摘 要： | 目的:检测FasL在大肠腺瘤、大肠癌及其肝转移中的表达,并分析FasL表达与临床病理特征间的关系.方法:应用免疫组化法检测83例大肠癌,20例大肠腺瘤,15例大肠癌肝转移中FasL的表达,表达结果与大肠癌病理特征、浸润深度和临床分期进行分析.结果:FasL表达在大肠癌中出现上调,与Dukes'分期,淋巴结和肝转移有关.大肠癌肝转移中全部表达FasL.结论:FasL表达的上调提示其在大肠癌发生,发展和转移中起重要作用.
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| 关 键 词： | 大肠癌 Fas配体 肝转移 |
| 文章编号： | 1000-8179(2004)01-0012-03 |
Expression of Fas Ligand in Colon Adenoma,Colorectal Cancer andLiver Metastases |
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| Zhang Wei Ding Er-xun Wang Qiang et al. Expression of Fas Ligand in Colon Adenoma,Colorectal Cancer andLiver Metastases[J]. Chinese Journal of Clinical Oncology, 2004, 31(1): 12-14 |
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| Authors: | Zhang Wei Ding Er-xun Wang Qiang et al |
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| Affiliation: | Zhang Wei Ding Er-xun Wang Qiang et al Department of General Surgery,Changzheng Hospital,Second Military Medical University,Shanghai |
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| Abstract: | Objective:To investigate the expression of Fas ligand in colon adenoma,col-orectal cancer and liver metasetase,and determine the relationship between FasL expression and tumor biological behaviors.Methods:FasL expression was detected by using immunohistochemical method.The staining characteristics were compared with degree of differentiation,serosal invasion and Duke's stage.Results:FasL expression upregulate in colorectal cancer,significant linear re-la tionship was found between FasL expression and Duke's stage,lymph node and liver metastases.All liver metastases express FasL.Conclusion:FasL expression upregulate in colorectal cancer,in dicate the importance of FasL in the pathogenesis and progression of tumor cells. |
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| Keywords: | Colorectal cancer Fas ligand Liver metastases |
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