5-HT(1A) receptor binding changes in patients with major depressive disorder before and after antidepressant treatment: A pilot [(18)F]MPPF positron emission tomography study |
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| Authors: | Amélie Lothe Mohamed Saoud Sandrine Bouvard Jérôme Redouté Jérôme Lerond Philippe Ryvlin |
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| Affiliation: | Université de Lyon, Lyon, France; Université Lyon 1, Villeurbanne, France; Institute for Children and Adolescents with Epilepsy (IDEE), Lyon, France; INSERM, U1028, Lyon Neuroscience Research Center, Tiger Team, Lyon, France; CNRS, UMR5292, Lyon Neuroscience Research Center, Tiger Team, Lyon, France. Electronic address: amelie.lothe@cermep.fr. |
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| Abstract: | ![]()
This is the first [(18)F]MPPF PET study in positron emission tomography study in depressed patients, both before and after treatment with a selective serotonin reuptake inhibitor (SSRI). Dynamic changes in [(18)F]MPPF binding potential were observed primarily in the medial orbital regions from baseline to 30days of treatment, suggesting SSRI-mediated serotoninergic adaptative mechanisms. |
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