Synthesis, molecular modelling and biological evaluation of 4-amino-2(1H)-quinazolinone and 2,4(1H,3H)-quinazolidone derivatives as antitumor agents |
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| Authors: | Richter Stephanie Gioffreda Barbara |
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| Affiliation: | Department of Pharmaceutical Chemistry, Heinrich Heine University, Düsseldorf, Germany. |
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| Abstract: | A series of 6-benzoyl-, 6-arylthio- and 6-arylsulfonyl-4-amino-2(1H)-quinazolinones and -2,4(1H,3H)-quinazolinediones were prepared. They were evaluated in vitro for their cytotoxicity against the NCI-60 cancer cell lines. |
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| Keywords: | 4‐Amino‐2(1H)‐quinazolinone Antitumor activity 2,4(1H,3H)‐Quinazolidone |
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