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| 复方克林霉素磷酸酯凝胶的制备及质量控制 | |
| 引用本文： | 李海涛,于学珍,林家红. 复方克林霉素磷酸酯凝胶的制备及质量控制[J]. 药学进展, 2006, 30(6): 270-273 |
| 作者姓名： | 李海涛 于学珍 林家红 |
| 作者单位： | 1. 南京中医药大学药理学教研室,江苏,南京,210046 2. 中国药科大学中药学院,江苏,南京,210009 |
| 摘 要： | 目的：研制复方克林霉素磷酸酯凝胶剂并建立质量控制标准。方法：用卡波姆-940作基质，三乙醇胺为中和剂，加入维A酸与克林霉素磷酸酯制成凝胶剂。采用紫外分光光度法和高效液相色谱法测定凝胶的含量。结果：制备的复方克林霉素磷酸酯凝胶剂细腻、光洁透明、稳定性好。结论：该凝胶剂配方合理，含量检测方法简便且可操作性强。 |
| 关 键 词： | 复方克林霉素磷酸酯凝胶 维A酸 质量控制 |
| 文章编号： | 1001-5094（2006）06-0270-04 |
| 修稿时间： | 2006-02-17 |
Preparation and Quality Control of Compound Clindamycin Phosphonolipid Gelata |
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| LI Hai-tao,YU Xue-zhen,LIN Jia-hong. Preparation and Quality Control of Compound Clindamycin Phosphonolipid Gelata[J]. Progress in Pharmaceutical Sciences, 2006, 30(6): 270-273 | |
| Authors: | LI Hai-tao YU Xue-zhen LIN Jia-hong |
| Affiliation: | 1. Department of Pharmacology, Nanjing University of Traditional Chinese Medicine, Nanjing 210046, China ;2. Department of Chinese Materia Medica, China Pharmacatical University, Nanjing 210009, China |
| Abstract: | Objective: To study the preparation and quality control of compound clindamycin phosphonolipid gelata.Methods: Carbopol-940 was used as base,and triethanol-amine as neutralizer.Clindamycin phosphonolipid and tretinoin were added to form gelata.UV spectrophotometry and high performance liquid chromatography were used to measure the drug content of the gelata.Results: The gelata was homogenous,transparent and stable.Conclusion: The formulation of the gelata is reasonable and the method for quality control was simple and rapid. |
| Keywords: | Compound clindamycin phosphonolipid gelata Tretinoin Quality control |
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