食管鳞癌中上皮细胞黏附分子蛋白高表达与临床病理特征的关系

目的 探讨食管鳞癌标本中Ep-CAM蛋白高表达与肿瘤浸润和转移之间的关系。方法 采用免疫组织化学PV-9000二步法检测140例石蜡包埋手术切除的食管鳞癌和20例癌旁正常食管上皮组织中Ep-CAM蛋白的表达，并对Ep-CAM蛋白高表达与患者临床病理特征之间的关系进行分析。结果 Ep-CAM在食管鳞癌组织中高表达85例（60.7%），癌旁正常组织中不表达。Ep-CAM高表达与患者的性别无关（P=0.142），与肿瘤长度、分化程度、TNM分期、浸润深度和有无淋巴结转移均相关（P<0.05）。结论 Ep-CAM与食管鳞癌的转移和浸润相关。

Relationship Between High Expression of Ep-CAM Protein and Clinicopathological Features of Esophageal Squamous Cell Carcinoma Tissues

Objective To explore the surgical relationship between high expression of Ep-CAM protein and the infiltration, metastasis of esophageal squamous cell carcinoma(ESCC) tissues. Methods The Ep-CAM expression was immunohistochemically investigated in 140 cases of primary SCC and 20 cases of adjacent non-neoplastic epithelia by PV-9000 polymer detection system for immuno-histological staining. And the relationship between clinicopathological features and high expression of Ep-CAM was analyzed. Results The high expression of Ep-CAM was observed in 85 cases(60.7%), but there was no high expression in adjacent normal tissues. Ep-CAM high expression were associated with tumor length, differentiation degree, TNM staging, infiltration depth and presence of lymph node metastasis(P<0.05), but age(P=0.142). Conclusion Ep-CAM is related to the infiltration and metastasis of ESCCs.