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| DNA修复酶HOGG1在食管鳞癌的表达和临床意义 | |
| 引用本文： | 张翔,胡江文,袁方良,高冲,成静,钱晓彬,吴莺,高大庆. DNA修复酶HOGG1在食管鳞癌的表达和临床意义[J]. 基础医学与临床, 2011, 31(1) |
| 作者姓名： | 张翔 胡江文 袁方良 高冲 成静 钱晓彬 吴莺 高大庆 |
| 作者单位： | 1. 东南大学医学院病原生物学与免疫学系,江苏南京,210009 2. 江苏省肿瘤医院胸外科,江苏南京,210009 3. 江苏大学基础医学和医学技术学院病理科,江苏镇江,212017 |
| 基金项目： | 江苏省自然科学基金(BK2007108,BK2008478); 东南大学人才引进科研启动基金(4023001015) |
| 摘 要： | 目的探讨食管鳞状上皮癌组织中DNA损伤修复酶HOGG1表达与8-oxoG氧化损伤的关系及其表达改变的临床意义。方法免疫组化和Western blot检测鳞癌和癌旁组织中HOGG1的表达和8-oxoG氧化损伤,TUNEL试剂盒检测组织的凋亡指数。相关性统计分析鳞癌组织HOGG1低表达与上述两项指标之间的相关性;χ2检验与秩和检验统计鳞癌组织中HOGG1低表达与临床病理特征之间的关系。结果 HOGG1在食管鳞癌患者的组织中均有不同程度的表达,并且存在个体差异,鳞癌组织中HOGG1表达明显低于其癌旁组织(P<0.05),8-oxoG的氧化损伤程度明显高于癌旁组织(P<0.05),鳞癌组织中HOGG1的低表达与该组织8-oxoG氧化损伤程度、细胞凋亡指数呈负相关,与鳞癌的静脉侵犯、淋巴结转移有关,与患者的年龄、性别、鳞癌组织的病理分化程度无关。结论 HOGG1可作为食管鳞癌术后的检测指标,指导患者术后个体化治疗方案的制定。 |
| 关 键 词： | 食管鳞癌 HOGG1 8-oxoG 凋亡 |
Expression of DNA repair enzyme HOGG1 in esophageal squamous cell carcinoma and its clinical significance |
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| ZHANG Xiang,HU Jiang-wen,YUAN Fang-liang,GAO Chong,CHENG Jing,QIAN Xiao-bin,WU Ying,GAO Da-qing. Expression of DNA repair enzyme HOGG1 in esophageal squamous cell carcinoma and its clinical significance[J]. Basic Medical Sciences and Clinics, 2011, 31(1) | |
| Authors: | ZHANG Xiang HU Jiang-wen YUAN Fang-liang GAO Chong CHENG Jing QIAN Xiao-bin WU Ying GAO Da-qing |
| Affiliation: | ZHANG Xiang1,HU Jiang-wen2,YUAN Fang-liang2,GAO Chong1,CHENG Jing3,QIAN Xiao-bin3,WU Ying3,GAO Da-qing1(1.Dept.of Pathogenic Organism and Immunology,Southeast University,210009 Nanjing,2.Dept.of Chest Surgery,Tumor Hospitalof Jiangsu Province,3.Pathology Department,Jiangsu University,Zhenjiang 212017,China) |
| Abstract: | Objective The relationship between expression of HOGG1 in esophageal squamous cell carcinoma(ESCC) tissues and its 8-oxoG oxidative damage was investigated.Methods The expression of HOGG1 protein and the 8-oxoG oxidative damage between ESCC tissues and the adjacent tissues were compared by immunohistochemistry and Western blot.TUNEL kit was used to detect the apoptosis index(AI) of these tissues.Results There was different HOGG1 expression in ECSS tissues and the adjacent tissues,and the differences of HOGG... |
| Keywords: | esophageal squamous cell carcinoma HOGG1 8-oxoG apoptosis |
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