口腔颌面部鳞癌CFC方案时辰化疗近期疗效及毒副作用观察

目的探讨CFC方案时辰化疗治疗颌面部鳞癌的疗效及毒副反应。方法15例颌面部鳞癌患者，采用CFC方案时辰化疗卡铂（CBP）、5-氟尿嘧啶（5-Fu）、甲酰四氢叶酸钙（CF）]，给药时间在16：00至次137：00，观察CFC方案化疗患者的疗效及毒副作用．化疗后10～21d手术。结果CFC方案时辰化疗后。完全缓解（CR）为3例，术后病理检查原发癌已查不到癌细胞．部分缓解（PR）为11例，无效（NR）为1例，总有效率（CR＋PR）为93．3％：而出现的毒副作用仅为轻度的疲倦、恶心、呕吐，以及WBC与RBC降低。结论CFC方案疗效确切．时辰化疗可明显减少患者化疗药物的毒副反应．值得临床推广应用。

Observation of therapeutic effect and toxic reaction of CFC regimen chrono-chemotherapy in treatment of oral and maxillofacial squamous cell carcinoma

Objective To evaluate therapeutic effect and toxic recation of CFC regimen chrono-chemotherapy in the treatment of maxillofacial squamous cell carcinoma. Methods 15 cases of maxillofacial squamous cell carcinoma were all treated by the CFC medicine project(Carboplatin; 5-Fluorouracil; Calcium Folinate). The Chrono-chemotherapy medicine was administrated from 16:00 to tomorrow 7:00. Therapeutic effect and toxicities were observed. The operation was performed in 10 ～ 21 days after chemotherapy. Results After chemotherapy, complete response (CR) was achieved in 3 case, partial response (PR) in 11 cases and no nesponse (NR) in 1 case. The overall response rate (CR+PR) was 93.3%. the Chrono-chemotherapy medicine has lower toxicities incidence rate, such as nausea, vomiting, descending WBC and RBC. Conclusion Chrono-chemotherapy, which has lower toxicities incidence, was potentially recommended for clinical application.