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目的 探讨儿童结核性脑膜炎临床特征与卡介苗(BCG)接种之间的关系.方法 将重庆医科大学附属儿童医院2004-2007年122例儿童结核性脑膜炎按是否接种BCG分为BCG组(54例)和未接种BCG组(68例),对临床资料进行回顾性分析.结果 0～5岁为发病高峰(67.2%);以农村患儿为主(72.1%);临床分期以中晚期为主,其中未接种BCG组的晚期发病例数明显高于BCG组,差异有统计学意义(P<0.05);BCG组临床预后明显好于未接种BCG组,差异有统计学意义(P<0.05);两组在临床特征及是否发生脑积水方面差异无统计学意义(P>0.05).结论 BCG组晚期结核性脑膜炎的发生率较未接种BCG组低,并且其预后好于未接种BCG组.

The clinical research of BCG vaccinated and unvaccinated in pediatric tuberculous meningitis

??Abstract??Objective??To study the relationship of clinical features between vaccinated and unvaccinated children with tuberculous meningitis??TBM??. Methods??A total of 122 hospitalised children ??54 vaccinated??68 unvaccinated?? were enrolled??using the clinical data for a retrospective study. Results??The peak incidence of age was from 0 to 5 years ??67.2%????most children were in rural areas ??72.1%??. The most common clinical stages were intermediated and advanced stages?? the vaccinated children being fewer than the unvaccinated ??38.9% VS 58.8%??P < 0.05??. The clinical prognosis of vaccinated children was better than unvaccinated ??P < 0.05??. No significant clinical feature and hydrencephaly differences were seen. Conclusion??The incidence of advanced stage of TBM of BCG vaccinated children is lower than unvaccinated children?? and children of BCG vaccinated have a better prognosis than unvaccinated children.