Relative contributions of innate and acquired host responses to bacterial control and arthritis development in Lyme disease |
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| Authors: | Wang Xiaohui Ma Ying Weis John H Zachary James F Kirschning Carsten J Weis Janis J |
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| Affiliation: | Department of Pathology, University of Utah School of Medicine, 30 North 1900 East, Salt Lake City, UT 84132-2501, USA. |
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| Abstract: | TLR2(-/-)/scid double-mutant mice were infected with B. burgdorferi to assess the relative importance of acquired and innate host defenses. Although spirochete levels at 4 weeks were lower in TLR2(-/-) mice than in TLR2(-/-)/scid mice, the increased arthritis severity of TLR2 (Toll-like receptor 2)-deficient mice was reduced by the presence of the scid mutation. |
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