Effect of iron deficiency anaemia and its treatment on single dose phenytoin bioavailability |
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| Authors: | M. V. Joshi S. M. Pohujani B. C. Mehta V. N. Acharya N. A. Kshirsasgar |
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| Affiliation: | (1) Department of Pharmacology and Clinical Pharmacology, Parel, Bombay, India;(2) Department of Clinical Pharmacology Unit of CDRI, Seth G.S. Medical College and K.E.M. Hospital, Parel, Bombay, India;(3) Department of Hematology, Seth G.S. Medical College and K.E.M. Hospital, Parel, Bombay, India;(4) Department of Medicine, Seth G.S. Medical College and K.E.M. Hospital, Parel, Bombay, India |
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| Abstract: | Summary Iron deficiency is a common nutritional deficiency, which leads to structural functional and enzymatic changes in the body that may affect the pharmacokinetics of drugs.The present study in 7 normal volunteers and 8 adult male patients with irondeficiency anaemia (IDA) was done to investigate the effect of iron deficiency and its treatment with total dose iron (TDI) on the bioavailability of a single dose of phenytoin. Phenytoin bioavailability was investigated before and 3 and 28 days after TDI.The bioavailability parameters Cmax, tmax, AUC and 2 h phenytoin concentrations were not significantly different in anaemic patients as compared to normal volunteers before or after treatment, except for an increase in tmax 28 days after TDI treatment. |
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| Keywords: | Iron deficiency anaemia Phenytoin bioavailability pharmacokinetics |
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