Early MRI findings in Creutzfeldt-Jakob disease |
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| Authors: | Marco Onofrj Tommaso Fulgente Domenico Gambi Giorgio Macchi |
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| Affiliation: | (1) Istituto di Neurologia, Università !["ldquo"]("/content/v80765w3l3346m76/xlarge8220.gif") G. D'Annunzio!["rdquo"]("/content/v80765w3l3346m76/xlarge8221.gif") , Chieti, Italy;(2) Istituto di Neurologia, Università Cattolica S.C.,, Rome, Italy;(3) Clinica Neurologica, Osp. ex-Pediatrico, Via Martiri Lancianesi, 6, I-66100 Chieti, Italy |
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| Abstract: | We describe the MRI changes preceding the onset of myoclonus in two patients whose post-mortem examination confirmed the diagnosis of Creutzfeldt-Jakob disease (CJD). MRI showed changes in the striatum early in the course of CJD (2–6 months after the onset of apathy, interpreted as depression, and 1–2 months before the onset of further clinical symptoms). Only in one patient did electroencephalography record the typical triphasic sharp-waves, 1 month after MRI. |
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| Keywords: | Creutzfeldt-Jacob disease Magnetic resonance imaging Computed tomography Electroencephalography |
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