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| mTOR在HER-2阴性乳腺癌中的表达及意义 | |
| 引用本文： | 王立波,;王彦荣,;席妍,;李晓萌. mTOR在HER-2阴性乳腺癌中的表达及意义[J]. 中国实验诊断学, 2014, 0(8): 1262-1264 |
| 作者姓名： | 王立波, 王彦荣, 席妍, 李晓萌 |
| 作者单位： | [1]吉林省肿瘤医院内二科,吉林长春130012; [2]吉林大学中日联谊医院内镜中心,吉林长春130012; |
| 基金项目： | 吉林省自然科学基金项目（项目编号201015233） |
| 摘 要： | 目的观察mTOR蛋白在Her-2阴性乳腺癌中的表达,探讨其与Her-2阴性乳腺癌发生发展相关性,为Her-2阴性乳腺癌寻找新的治疗靶点。方法采用免疫组织化学技术检测65例Her-2阴性乳腺癌、癌旁组织及正常乳腺组织中mTOR的表达情况。结果 Her-2阴性乳腺癌组织中mTOR蛋白表达明显高于癌旁组织及正常乳腺组织,差异有统计学意义（P〈0.05）。mTOR阳性表达在腋窝淋巴结阳性组明显高于淋巴结阴性组,差异有统计学意义（P〈0.05）。结论 mTOR可能与Her-2阴性乳腺癌发生与发展相关,与腋窝淋巴结转移相关,可作为Her-2阴性乳腺癌的预后指标及新的治疗靶点。 |
| 关 键 词： | mTOR Her-2阴性 乳腺肿瘤 |
Expression and significance of mTOR in Her-2 negative breast cancer |
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| Affiliation: | WANG Li-bo ,WANG Yan-rong ,XI Yan ,et al. (Jilin Province Tumour Hospitol of Chemotherapy 2 Department,Changchun 130012,P. R. China) |
| Abstract: | Objective We examined the expression of mTOR protein in Her-2negative breast cancer.Discussits clinical significance and looks for new therapeutic target for Her-2negative breast cancer.Methods mTOR were determined immunohistochemically in 65 cases of Her-2 negative breast cancer,tumor-adjacent tissues and normal tissues.Results Positive mTOR expression was noted in Her-2negative breast cancer apparently higher than tumor-adjacent tissues and normal tissues（P〈0.05）.it was also obviously higher in group with axillary lymphnode metastasis than in group with out lymphnode metastasis（P〈0.05）.Conclusion Expression of mTOR？significantly increased in Her-2negative breast cancer.The detection of mTOR play an important role in tumorigenesi,it has significant correlation with axillary lymphnode metastasiss,and provide a new road for trentment of Her-2 negative breast cancer. |
| Keywords: | mTOR Her-2nagative breast cancer |
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