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| 豚鼠M细胞缓慢激活型延迟整流钾电流对缺血的反应 | |
| 引用本文： | 郭新辉,尹炳生,周翔,农德斌,朱浩,李本富,哈德旷,王伟,陈允钦. 豚鼠M细胞缓慢激活型延迟整流钾电流对缺血的反应[J]. 心血管康复医学杂志, 2002, 11(5): 407-409 |
| 作者姓名： | 郭新辉 尹炳生 周翔 农德斌 朱浩 李本富 哈德旷 王伟 陈允钦 |
| 作者单位： | 第一军医大学心电研究中心,广东,广州,510515 |
| 摘 要： | 目的：研究缺血对豚鼠心室M细胞缓慢激活型延迟整流钾通道电流（Iks)的影响。方法：利用全细胞膜片钳技术观察豚鼠心室M细胞Iks，利用不同成分浴槽液模拟细胞正常及缺血坏死，观察Iks尾电流锋值的变化情况。结果：指令电压≥0mV时，缺血组电流显小于正常组，P＜0．05；指令电压小于0mV时，两组间无显性差异，P＞0．05。结论：缺血时M细胞Iks显减弱，可能会增加心室壁电活动不均一性，促使心律失常的发生。 |
| 关 键 词： | 心室肌细胞 缺血 缓慢激活延迟整流钾通道电流 心律失常 |
| 文章编号： | 1008-0074(2002)05-0407-03 |
| 修稿时间： | 2002-02-21 |
The effects of ischemia on delayed rectifier potassium current in guinea pig M cell |
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| GUO Xin-hui,YIN Bing-sheng,ZHOU Xiang,et al.. The effects of ischemia on delayed rectifier potassium current in guinea pig M cell[J]. Chinese Journal of Cardiovascular Rehabilitation Medicine, 2002, 11(5): 407-409 | |
| Authors: | GUO Xin-hui YIN Bing-sheng ZHOU Xiang et al. |
| Affiliation: | GUO Xin-hui,YIN Bing-sheng,ZHOU Xiang,et al.Resarch Center of Electrocardiology,First Military Medical University,Guangzhou,510515 |
| Abstract: | Objective: To study the effects of ischemia on slow activating delayed rectifier potassium current (Iks) in guinea pig M cell. Methods: In isolated M cell ?we simulated the normal and ischemia environment with different composition of bath solution and recorded the M cell Iks tail current by the whole cell patch-clamp technique. Results: When test potential>0 mV, Iks decreased significantly under ischemia condition, P<0. 05. When test potentiaK OmV, there was no significant different between two groups, P>0. 05.Conclusion: M cell Iks decreased significantly under ischemia condition. It may enhance the electrophysiological heterogeneity of ventricle and leading to the development of cardiac arrythmias. |
| Keywords: | Ventricular myocytes Ischemia Slow activating delayed rectifier potassium current (Iks) Arrhythmia |
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