肺硬化性血管瘤12例病理分析

目的探讨肺硬化性血管瘤(SHL)的组织起源、病理特征及特异性病理诊断指标。方法对12例SHL组织标本进行甲状腺转录因子-1(TTF-1)、上皮膜抗原(EMA)、CK7、CK20、突触泡蛋白(Syn)、波形蛋白(Vimentin)、平滑肌肌动蛋白(SMA)、胎盘碱性磷酸酶(PLAP)、嗜铬粒蛋白(CgA)、CD34的SP免疫组织化学法标记,其中10例做电镜观察。结果SHL组织结构多样化,主要表现为实性、乳头状、血管瘤样和硬化4种结构,瘤细胞由表面立方细胞和多角形细胞组成。所有的多角形和表面立方细胞同时表达TTF-1、EMA,电镜下见多角形细胞中有少量电子致密颗粒。结论TTF-1及EMA等免疫标记物对SHL的诊断具有十分重要的价值。SHL可能起源于多潜能的原始呼吸道上皮细胞。

Pathological analysis of pulmonary sclerosing hemangioma:12 cases report

Objective To investigate the characteristic of histogenesis and pathologic of pulmonary sclerosing hemangioma of the lung(SHL)and its specific diagnostic indexes in pathology.Methods Retrospective analysis 12 cases of SHL.All specimens were immunostained with a panel of antibodies including TTF-1,EMA,CK7,CK20,Syn,cytokeratin,etc.Ten of them were underwent electron microscopy analysis.Results All cases exhibited the classic histologic features with variable 4 types,including solid,papillary,hemorrhagic or hemangiomatic,and sclerotic pattern.The tumors cell consisted of solid sheets or aggregates of pale polygonal cells and papillae and clefts lined by cuboidal or columnar cells.The expression of both TTF-1 and EMA were positively in the surface of lining cuboidal cells and the pale polygonal cells.A small amount of granules was validated in the polygonal cells by electronic microscopy.Conclusion The immunohistochemical markers such as TTF-1,EMA and CK played an important role in diagnosing SHL.It is suggested that SHL may be derived from primitive respiratory epithelium cells.