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| “抓取测试盒”对局灶脑缺血大鼠前肢功能的评价 | |
| 引用本文： | 周佳丽,祝慧凤,万东,徐晓玉,陈怡,陈红.“抓取测试盒”对局灶脑缺血大鼠前肢功能的评价[J].中国药理学通报,2008,24(11). |
| 作者姓名： | 周佳丽 祝慧凤 万东 徐晓玉 陈怡 陈红 |
| 作者单位： | 1. 重庆医药高等专科学校 2. 西南大学药学院暨中医药学院 3. 重庆医科大学附属第一医院急诊科 4. 第三军医大学西南医院药剂科,重庆,400016 |
| 基金项目： | 国家自然科学基金,重庆市自然科学基金 |
| 摘 要： | 目的探讨"抓取测试盒"评价局灶脑缺血大鼠受累前肢精细运动功能的可行性及有效性。方法实验筛选"左利手"SD大鼠30只,随机分为正常组、假手术组、模型组、生理盐水组、胞二磷胆碱组,每组6只。假手术组仅开颅暴露大脑中动脉(MCAO),模型组用电凝法制成局灶性脑缺血大鼠模型;用压克力板材料做成抽屉式的"抓取测试盒",比较各组大鼠在所选5个时间点的前肢抓取能力。结果各组大鼠在造模前"抓取成功率基线值"差异无统计学意义(P>0.05);模型组分别与正常组及假手术组组间比较,抓取成功率降低,差异有显著性(P<0.05);胞二磷胆碱组与模型组比较,4d、7d、15d、21d抓取成功率升高,差异有显著性(P<0.05)。结论"抓取测试盒"能客观测试和反映大鼠前肢抓取能力,反映大鼠前肢抓取功能恢复程度。 |
| 关 键 词： | 抓取测试 前肢 大鼠 局灶性脑缺血 |
Evaluation of Grasping test box on the forelimb function of focal cerebral ischemia rats |
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| ZHOU Jia-li,ZHU Hui-feng,WAN Dong,XU Xiao-yu,CHEN Yi,CHEN Hong.Evaluation of Grasping test box on the forelimb function of focal cerebral ischemia rats[J].Chinese Pharmacological Bulletin,2008,24(11). | |
| Authors: | ZHOU Jia-li ZHU Hui-feng WAN Dong XU Xiao-yu CHEN Yi CHEN Hong |
| Institution: | ZHOU Jia-li1,ZHU Hui-feng2,WAN Dong3,XU Xiao-yu2,CHEN Yi2,CHEN Hong4(1.Chongqing Medical , Pharmaceutical College,2.School of Pharmaceutical Sciences , School of Chinese Medicine,Southwest University,3.Dept of Emergency,the First Affiliated Hospital of Chongqing Medical University,4.Pharmacy in southwest Hospital of the Third Military Medical University,Chongqing 400016,China) |
| Abstract: | Aim To probe the feasibility and efficacy of the Grasping test box evaluating the forelimb which was to be involved in grasping function of focal cerebral ischemia rats.Methods The 30 left-handed Sprague-Dawley rats were randomly divided into 5 groups:normal group,sham operation group,model group,normal saline group and citicoline treatment group,with 6 in each group.Sham operation group only exposed the middle cerebral artery,and the operation group was made to the focal cerebral ischemia by electric coagu... |
| Keywords: | grasping-test forelimb rats cerebral ischemia |
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