| Caspase抑制剂的若干药理学研究进展 |
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| 引用本文： | 张宏涛,袁守军,李正强. Caspase抑制剂的若干药理学研究进展[J]. 中国临床药理学与治疗学, 2004, 9(3): 241-244 |
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| 作者姓名： | 张宏涛 袁守军 李正强 |
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| 作者单位： | 军事医学科学院放射医学研究所药理毒理室,北京,100850 |
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| 基金项目： | 全军十五指令性课题资助项目 (№ 0 1L0 2 2 ) |
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| 摘 要： | 细胞凋亡 (apoptosis)失衡与许多疾病密切相关 ,而半胱天冬氨酸蛋白酶 (caspase)是执行细胞凋亡的蛋白酶家族 ,在凋亡过程中发挥关键作用 ,它可通过多种途径发生级联激活。一些天然和合成的caspase抑制剂能够抑制caspase家族中的一种或几种成员而发挥抗凋亡作用 ,有望成为治疗细胞过度凋亡而引起的相关疾病的有效手段。
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| 关 键 词： | 细胞凋亡 Caspase 抑制剂 细胞保护 |
| 文章编号： | 1009-2501(2004)03-0241-04 |
| 修稿时间： | 2003-09-08 |
Progress of caspase inhibitors in pharmacology |
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| ZHANG Hong Tao,YUAN Shou Jun,LI Zheng Qiang. Progress of caspase inhibitors in pharmacology[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2004, 9(3): 241-244 |
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| Authors: | ZHANG Hong Tao YUAN Shou Jun LI Zheng Qiang |
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| Affiliation: | ZHANG Hong Tao,YUAN Shou Jun,LI Zheng Qiang Department of Pharmacology,Institute of Radiation Medicine,Academy of Military Medical Sciences,Beijing 100850,China |
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| Abstract: | Apoptosis is involved in a variety of diseases. Cysteine aspartate specific protease (caspase), a protease family which executes apoptosis, plays a crucial role in course of apoptosis. It can be activated through various pathways. Some natural and synthetic caspase inhibitors will strengthen anti apoptotic action through inhibiting one or several caspase activity, and will become effective means in treating diseases caused by overapoptosis. |
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| Keywords: | apoptosis caspase inhibitor cytoprotection |
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