|
|||||
|
|
No evidence of association from transmission disequilibrium analysis of the hKCa3 gene in bipolar disorder |
|
| Authors: | Bowen T Ashworth L Kirov G Guy C A Jones I R McCandless F Craddock N O'Donovan M C Owen M J |
| Affiliation: | Division of Psychological Medicine, University of Wales College of Medicine, Cardiff,;Division of Neuroscience, University of Birmingham, Queen Elizabeth Psychiatric Hospital, Birmingham and;Division of Medical Genetics, University of Wales College of Medicine, Cardiff, UK |
| Abstract: | Objective: A recent case–control study has suggested that modest enlargements of a highly polymorphic CAG repeat in exon 1 of the gene encoding potassium channel hKCa3 may be associated with bipolar disorder (BPD). We have examined this hypothesis by genotyping this locus in a family-based association study. Method: One hundred and twenty-eight parent–offspring trios of British Caucasian origin were examined where the proband was diagnosed with the American Psychiatric Association's Diagnostic and Statistical Manual (DSM)-IV BPD I (n=123) or II (n=5). An improved assay was used, with redesigned polymerase chain reaction (PCR) primers, permitting quicker and higher resolution genotyping. The resultant genotypes were analysed using the extended transmission/disequilibrium test (ETDT). Results: The experimental data did not provide evidence for the preferential transmission of large alleles to bipolar cases (χ2=11.12, df=10, p=0.349). Conclusions: Our data provide no support for the hypothesis that variation at the hKCa3 gene contributes to susceptibility to BPD. |
| Keywords: | bipolar disorder hKCa3 human potassium channel gene polymorphic CAG repeat |
| 本文献已被 PubMed 等数据库收录！ | |