| 星点设计-效应面优化黄芩苷乳酸-羟基乙酸共聚物纳米粒制备工艺研究 |
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| 引用本文： | 杨金艳,吴诗惠,罗明霞.星点设计-效应面优化黄芩苷乳酸-羟基乙酸共聚物纳米粒制备工艺研究[J].成都中医药大学学报,2010,33(4):75-80. |
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| 作者姓名： | 杨金艳 吴诗惠 罗明霞 |
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| 作者单位： | 四川省中西医结合医院,四川成都,610041;四川省中医药科学院,四川成都,610041;安岳县中医院,四川安岳,642350 |
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| 基金项目： | 江西省自然科学基金项目(编号:2007GQY0954) |
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| 摘 要： | 目的：优化黄芩苷乳酸-羟基乙酸共聚物纳米粒的处方工艺。方法：采用改进的复乳化-溶剂挥发法制备黄芩苷PLGA纳米粒,以纳米粒的包封率、载药量、粒径及总评＂归一值＂为评价指标,采用中心复合设计-效应面优化法考察聚乙烯醇（PVA）浓度与PLGA浓度对制备工艺的影响,对结果进行多元线性回归和二项式拟合,效应面法优选最佳工艺条件,并进行预测分析,同时采用扫描电镜和粒度分布仪观察纳米粒的表面形态和粒径分布。结果：从复相关系数上看,各指标二项式拟合方程均优于多元线性回归方程,根据优化工艺条件下制得纳米粒大小均匀,表面光滑圆整,平均粒径为（186.23±2.98）nm,包封率为（68.23±1.93）%,载药量为（8.44±0.58）%。结论：优化的黄芩苷乳酸-羟基乙酸共聚物纳米粒制备工艺稳定可行,可以用于生产。
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| 关 键 词： | 黄芩苷 乳酸-羟基乙酸共聚物 纳米粒 星点设计 效应面法 |
Optimized Preparation of Baicalin-loaded Polylactic-co-glycolic Acid Nanoparticles by Central Composite Design-response Surface Methodology |
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| YANG Jin-yan
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WU Shi-hui
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LUO Ming-xia.Optimized Preparation of Baicalin-loaded Polylactic-co-glycolic Acid Nanoparticles by Central Composite Design-response Surface Methodology[J].Journal of Chengdu University of Traditional Chinese Medicine,2010,33(4):75-80. |
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| Authors: | YANG Jin-yan WU Shi-hui LUO Ming-xia |
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| Institution: | YANG Jin-yan1,WU Shi-hui2,LUO Ming-xia3(1.Sichuan Hospital of Integrated Traditional Chinese Medicine,Chengdu 610041,China,2.Sichuan Academy of Chinese Medicine Sciences,3.Anyue Hospital of Traditional Chinese Medicine Ziyang 642350,China) |
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| Abstract: | Objective: Optimized formulation of baicalin-loaded polylactic-co-glycolic acid(PLGA) nanoparticles(BC-PLGA-NP).Methods: A series of baicalin-loaded PLGA nanoparticles have been prepared by w/o/w emulsion solvent evaporation method.The effects of influence factors such as the weigh of PLGA and PVA,on mean diameter,entrapment efficiency,drug loading and overall desirability were investigated by using central composite design and response surface method.The data were imitated using multi-linear equation and s... |
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| Keywords: | Baicalin polylactic-co-glycolic acid nanoparticles central composite design response surface method |
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