Lipid peroxidation induced by N-acetylcysteine in isolated rat hepatocytes |
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| Authors: | M Dore L Atzori L Congiu |
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| Affiliation: | 1. Watanabe Oyster Laboratory Co. Ltd., 490-3, Shimoongata-cho, Hachioji, Tokyo 192-0154, Japan;2. Faculty of Health Sciences, Hokkaido University, Sapporo 060-0812, Japan;3. Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, Japan;4. Food Processing Research Center, Hokkaido Research Organization, Ebetsu 069-0836, Japan;1. Bone Marrow Transplant and Immune Deficiency, Cincinnati Children''s Hospital Medical Center, Cincinnati, Ohio;2. Department of Infectious Disease, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas;3. Seattle Children''s Hospital, Seattle, Washington;4. Pediatric Blood and Marrow Transplant Program, Duke University Medical Center, Durham, North Carolina;5. Chimerix, Durham, North Carolina |
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| Abstract: | In isolated rat hepatocytes N-acetylcysteine induces an increase of lipid peroxidation, as evaluated by the malondialdehyde production and diene conjugation. Lipid peroxidation did not result in increased cell mortality. Antioxidants and free radicals scavengers completely protect toward lipid peroxidation induced by N-acetylcysteine. |
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