| Treg/Th17细胞分化失衡与炎症性肠病 |
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| 引用本文： | 邱新运,于成功. Treg/Th17细胞分化失衡与炎症性肠病[J]. 胃肠病学, 2011, 16(8): 499-502. DOI: 10.3969/j.issn.1008-7125.2011.08.014 |
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| 作者姓名： | 邱新运 于成功 |
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| 作者单位： | 1. 南京医科大学附属鼓楼临床医学院消化内科 210008
2. 南京医科大学附属鼓楼临床医学院消化内科 210008;南京大学医学院附属鼓楼医院消化内科 |
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| 摘 要： | 炎症性肠病（IBD）的病因和发病机制尚未完全明确,初始CD4~＋T细胞分化异常在其发生、发展过程中起重要作用。初始CD4~＋T细胞可分化为调节性T细胞（Treg细胞）和Th17细胞,Treg/Th17细胞间的失衡将导致包括IBD在内的多种自身免疫病的发生。初始CD4~＋T细胞周围的细胞因子和芳香烃受体对维持该平衡起重要作用。本文就Treg细胞和Th17细胞及其与IBD的关系作一综述。
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| 关 键 词： | T淋巴细胞,调节性 T淋巴细胞,辅助诱导 炎症性肠病 细胞因子类 |
Imbalance of Treg/Th17 Cells Differentiation and Inflammatory Bowel Disease |
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| QIU Xinyun,YU Chenggong. Imbalance of Treg/Th17 Cells Differentiation and Inflammatory Bowel Disease[J]. Chinese Journal of Gastroenterology, 2011, 16(8): 499-502. DOI: 10.3969/j.issn.1008-7125.2011.08.014 |
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| Authors: | QIU Xinyun YU Chenggong |
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| Affiliation: | QIU Xinyun,YU Chenggong. Department of Gastroenterology,Gulou School of Clinical Medicine,Nanjing Medical University,Nanjing(210008) |
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| Abstract: | The etiology and pathogenesis of inflammatory bowel disease(IBD) have not been well clarified,the abnormal differentiation of naive CD4~+ T cells is believed to play a critical role in the development of IBD.Naive CD4~+ T cells can differentiate into regulatory T cells(Treg cells) and Th17 cells,the imbalance of Treg/Th17 cells will cause various kinds of autoimmune disease including IBD.Cytokines around the naive CD4~+ T cells and aryl hydrocarbon receptor play important roles in maintaining the balance.Th... |
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| Keywords: | T-Lymphocytes Regulatory Helper-Inducer Inflammatory Bowel Disease Cytokines |
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