31例伏立康唑不良反应／事件文献分析

目的探讨伏立康唑不良反应／事件的发生原因与规律，为临床安全用药提供参考。方法对31例国内文献报道的伏立康唑不良反应／事件进行统计和分析。结果男性患者多于女性，60岁以上患者占61．29％；64．52％的病例明确有合并用药情况，其中8例怀疑因合并用药引发不良反应／事件；不良反应／事件可发生在用药过程中和用药后的各个时间段，且累及多个系统一器官。结论临床医务人员应注意询问患者的过敏史，并结合患者的基因类型使用该药；应严格遵照说明书用药、及时进行药物浓度监测与加强药品不良反应监测。

Literature Analysis of 31 Adverse Drug Reaction/Event Cases Induced by Voriconazole

Objective To discuss the causes and characteristics of the adverse drug reaction/event（ADR/ADE） cases induced by voriconazole in order to provide references for clinical rational drug use. Methods 31 ADR/ADE cases induced by voriconazole have been analyzed retrospectively. Results The number of male patients was more than the female. Patients over 60 years old accounted for 61.29%. 64.52% of the patients had combined medication, and it＇s suspected that concomitant medication resulted in 8 ADR/ADE cases. ADR/ADE can occur in the course of medication and after medication. The ADR/ADE involving multiple systems and organs. Conclusion Clinicians should pay attention to allergies and the genetic type of patients. The drug instruction should be adhered to. Drug monitoring should be timely done. The monitoring of adverse drug reactions should been strengthened.