磷霉素治疗细菌性痢疾的疗效及不良反应的文献分析

目的通过对磷霉素治疗细菌性痢疾的文献报道进行分析,评价磷霉素对细菌性痢疾的疗效及不良反应,以期为临床安全合理用药提供参考。方法以"磷霉素"并含"细菌性痢疾"为主要检索词,检索CNKI数据库1980~2012年间涉及磷霉素治疗细菌性痢疾的文献报道,分别从治愈、有效、无效3个疗效标准及不良反应的发生情况等方面进行统计分析。结果共检索出32篇2 911例病例,治愈2 708例(93.03%),有效179例(6.15%);无效24例(0.82%);发生不良反应63例(2.16%)。结论采用磷霉素治疗细菌性痢疾疗效明显,不良反应症状轻且发生率低,在临床治疗细菌性痢疾方面值得选用。

Literature Analysis of Curative Effect and Adverse Drug Reaction of Bacillary Dysentery Treated by Fosfomycin

Abstract：Objective To analyze the curative effect and adverse drug reaction of bacillary dysentery treated by fosfomycin. Methods Actual data related to bacillary dysentel-y treated by fosfomycin spanning years 1980-2012 were collected from the China National Knowledge Infrastructure（CNKI）. Datas should be analyzed through cure, effective, invalid and adverse drug reaction. Results Actual data originated from 32 publications encompassing 2911 cases including 2708 cases of cure, 179 cases of effective, 24 cases of invalid and 63 cases of adverse drug reaction. Conclusion There were obvious curative effect and low incidence rate of adverse drug reaction in bacillary dysentery treated by fosfomycin.