五酯胶囊对肾移植受者他克莫司血浓度影响的临床研究

目的：研究五酯胶囊（Wuzhi-capsule，WZ）与他克莫司（Tacrolimus，Tac）联合应用对肾移植受者Tac血浓度的影响。方法：45名服用Tac＋WZ患者为试验组，45名单服Tac患者为对照组，以Tac全血浓度及肝、肾功能生化检测指标作为临床评价指标。结果：合用WZ患者Tac全血浓度与合用前比较明显增加（P〈0．01），与对照组比较亦有显著性提高（P〈0．01）。WZ与Tac合用对肝、肾功能无明显影响。结论：WZ能明显升高肾移植受者Tac血浓度。在升高Tac血浓度的同时，WZ并不增加Tac的肝肾毒性反应。WZ与Tac合用可减少Tac用药量，节省Tac费用。

Clinical study for the effects of Wuzhi-capsule on blood concentration of tacrolimus in renal transplant recipients

To study the effects of Wuzhi-capsule (WZ) on the blood concentrations of Tacroli-mus (Tac) in renal transplant recipients. METH-ODS: The renal transplant recipients were divided into experimental group (45 cases) which treated with Tac plus WZ and control group (45 cases) which were re-ceived Tac alone. The blood concentrations of Tac and biochemical values of hepatic and renal functions were determined. RESULTS: The blood concentrations of Tac were significantly higher in experimental group than those in experimental group before combined with WZ( P < 0.01) or in control group ( P < 0.01) . The biochemical values of hepatic and renal functions be-tween experimental group and control group were no significant difference. CONCLUSION: The WZ can markedly elevate the blood concentrations of Tac in re-nal transplant recipients and does not increase the liver and kidney toxicity of Tac at the same time. The treat-ment of WZ combined with Tac can reduce the dosages and costs of Tac in renal transplant recipients.