| 复方盐酸伪麻黄碱缓释片的研究 |
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| 引用本文： | 苗爱东 崔玉琴. 复方盐酸伪麻黄碱缓释片的研究[J]. 中国医药工业杂志, 1995, 26(10): 446-449 |
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| 作者姓名： | 苗爱东 崔玉琴 |
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| 作者单位： | 空军乌鲁木齐医院药剂科，新疆医学院药剂教研室 |
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| 摘 要： | 应用反相ＨＰＬＣ法测定血药浓度，对复方盐酸伪麻黄碱缓释片的体外溶出及兔灌服一次的药物动力学进行了研究，并与自制普通片进行对照。结果表明缓释片维持体内有效血药浓度的时间较长，其相对生长利用度为１２２．４８％。体内外显著相关。理论值与实测值基本相符。
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| 关 键 词： | 盐酸伪麻黄碱 缓释片 溶出度 生物利用度 |
STUDIES ON COMPOUND SUSTAINED-RELEASE TABLETS OF PSEUDOEPHEDRINE |
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| MIAO Ai-Dong, CUI Yu-Qin,SUN Dian-Jia,MAI Er-Dana. STUDIES ON COMPOUND SUSTAINED-RELEASE TABLETS OF PSEUDOEPHEDRINE[J]. , 1995, 26(10): 446-449 |
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| Authors: | MIAO Ai-Dong CUI Yu-Qin SUN Dian-Jia MAI Er-Dana |
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| Abstract: | Using RP-HPLC method for determining the serum levels of pseudoephedrine hydrochloride(1.HCl), the dissolution rate of compound 1.HCl sustained-release tablets(SRT) and their pharmacokinetics in rabbits after oral administration of single dose were studied and compared with the ordinary tablets. The results showed that the compound 1 . HCl SRT released the drug with a first-order kinetics and a significant correlation was found between in vivo dissolution and in vivo absorption. |
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| Keywords: | pseudoephedrine hydrochloride sustained-release tablets dissolution rate bioavailability RP-HPLC |
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