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| 油中干燥法制备甘氨酸茶碱钠微囊及其释药特性的研究 | |
| 引用本文： | 陆锦芳 柳晨. 油中干燥法制备甘氨酸茶碱钠微囊及其释药特性的研究[J]. 中国医药工业杂志, 1995, 26(10): 443-446 |
| 作者姓名： | 陆锦芳 柳晨 |
| 作者单位： | 上海医科大学药学院药剂学教研室 |
| 摘 要： | 采用油中干燥法，以ＥｕｄｒａｇｉｔＲＳ１００和Ｅｕｄｒａｇｉｔ ＲＬ１００为囊材制备水溶性药物甘氨酸茶碱钠微囊。实验结果表明，所得微囊能延缓药物的释放，且以ＥｕｄｒａｇｉｔＲＳ１００为囊材制得到的微囊缓释性能较优。 |
| 关 键 词： | 油中干燥法 微囊 甘氨酸茶碱钠 释药性 |
PREPARATION AND DISSOLUTION PATTERN OF EUDRAGIT MICROCAPSULES CONTAIN IN THEOPHYLLINE SODIUM GLYCINATE |
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| LU Jin-Fang,LIU Chen,JIAO Zheng, XIAO Bing. PREPARATION AND DISSOLUTION PATTERN OF EUDRAGIT MICROCAPSULES CONTAIN IN THEOPHYLLINE SODIUM GLYCINATE[J]. , 1995, 26(10): 443-446 | |
| Authors: | LU Jin-Fang LIU Chen JIAO Zheng XIAO Bing |
| Abstract: | The microcapsules containing theophylline sodium glycinate with solid dispersing agent were prepared by solvent evaporation technique in a liquid paraffin medium. The copolymers of Eudragit-RL100 and Eudragit-RS100 were used for microcapsule material. In vitro it was found that the drug release rate decreased with increasing microcapsule material and the drug release rate of Eudragit-RS100 microcapsules was slower than that of Eudragit-RL100 microcapsules. Drug release appeared to fit Higuchi matrix model kinetics. |
| Keywords: | microcapsule liquid drying process Eudragit-RS Eudragit-RL theophylline sodium glycinate |
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