喉癌前病变100例分析

对１００例喉癌前病变进行临床及病理学分析。发现喉癌前病变的发病和过度使用嗓音及长期大量吸烟有密切关系。其病理表现为上皮典型增生及轻、中、重度非典型增生（亦称异型）。扫描电镜观察到随喉粘膜上皮细胞异型程度的增加，细胞表面形状、大小、边缘、细胞间连接等有显著不同。１００例中有２０例转为恶性。其中，慢性肥厚性喉炎的恶变率为１１．６％，喉角化症为１９％，喉乳头状瘤为３６％。临床表现及病理均证明为喉息肉的病例也有恶性变者，故临床上应加以警惕。

Analysis of 100 Cases of Precancerous Laryngeal Lesions

Hand red cases of preca ncerous laryngeal lesions were a nalysed on the hsis of clinical pathology, The results showed that there was close relation between the precancerous laryngeal lesions and voice abuse and long-term heavy smoking.The pathology showed epithelial hyperplasis and mild to severe atypical hyperplasia(heterotype).Scanning electronmicroscopy revealed that the more severe thedegree of the epithelial heterotype,the more pleomorphic the shape of cell morphology,margin. Twen-ty cases had malignant changes later,and the rate of malignant change was high in those with atypical hyperplasia. Some lesions which were taken for polyps clinically and pathologycally could also have ma-lignant changes,so more attention should be paid to these lesions during clinical management.